Changes in ALFF and ReHo values in methamphetamine abstinent individuals based on the Harvard-Oxford atlas: A longitudinal resting-state fMRI study.
Changes in ALFF and ReHo values in methamphetamine abstinent individuals based on the Harvard-Oxford atlas: A longitudinal resting-state fMRI study.
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甲基苯丙胺（MA）滥用已成为一个全球性的公共卫生问题，因为它损害了整个身体的各个系统，特别是中枢神经系统。然而，静息状态脑功能在短期和长期禁欲之间的差异、治疗的利弊以及静息状态脑功能与行为测试之间的关系尚不清楚。对63名MA戒断者进行了近1年的随访，并采用三种不同的治疗方法。通过静息状态功能磁共振成像（fMRI）测量基于哈佛-牛津图谱（HOA）的低频波动幅度（ALFF）和区域均匀性（ReHo）。冲动性采用Barratt冲动性量表- 11 （BIS - 11）进行评估。与短期戒断组相比，长期戒断组ALFF和ReHo值显著升高的大脑区域位于右额极（McKetin et al., 2012, https://doi.org/10.1111/j.1360-0443.2012.03933.x）和右额中回（Wang et al., 2015, https://doi.org/10.1371/journal.pone.0133431）周围。在经历长期禁欲的三组之间没有显著差异。右侧额中回ALFF和ReHo的变化与BIS总分、BIS注意评分和BIS非计划性评分有显著相关。在接受治疗性干预的MA长期戒断个体中，右侧额叶中回是一个关键区域，当与BIS - 11结合使用时，该区域可能是有用的，可作为识别MA个体戒断与治疗性干预效果的潜在生物标志物。与短期戒断组相比，长期戒断组显示两个区域的低频波动幅度（ALFF）和区域均匀性（ReHo）值均增加：右额极(2)和右额中回(8)。右侧额中回与Barratt冲动性量表（BIS）总分、BIS注意得分和BIS非计划性得分相关。因此，当与BIS‐11结合使用时，右侧额叶中回是一个关键区域，可作为鉴定甲基苯丙胺（MA）个体戒断治疗干预效果的潜在生物标志物。
Methamphetamine (MA) abuse has become a global public health problem due to damage to various systems throughout the body, especially the central nervous system. However, the differences in resting‐state brain function between short‐term and long‐term abstinence, the pros and cons of treatments, and the relationship between resting‐state brain function and behavioral tests are unknown. Sixty‐three MA abstinent individuals were followed up for nearly 1 year and treated with three different methods. The amplitude of low‐frequency fluctuation (ALFF) and regional homogeneity (ReHo) based on the Harvard‐Oxford atlas (HOA) were measured by resting‐state functional magnetic resonance imaging (fMRI). Impulsivity was evaluated by the Barratt Impulsivity Scale‐11 (BIS‐11). Brain regions with significant increases in ALFF and ReHo values in the long‐term abstinent group compared to the short‐term abstinent group were around the right frontal pole (McKetin et al., 2012, https://doi.org/10.1111/j.1360-0443.2012.03933.x) and right middle frontal gyrus (Wang et al., 2015, https://doi.org/10.1371/journal.pone.0133431). There were no significant differences among the three groups that experienced long‐term abstinence. The changes in ALFF and ReHo in the right middle frontal gyrus were significantly associated with BIS total scores, BIS attention scores, and BIS nonplanning scores. The right middle frontal gyrus is a critical region in MA long‐term abstinent individuals exposed to therapeutic intervention, and this region may be useful, when combined with BIS‐11, as a potential biomarker to identify the effect of abstinence with therapeutic intervention in MA individuals. Compared with the short‐term abstinent group, the long‐term abstinent group showed two areas where both amplitude of low‐frequency fluctuation (ALFF) and regional homogeneity (ReHo) values increased: right frontal pole (2) and right middle frontal gyrus (8). The right middle frontal gyrus was associated with Barratt Impulsivity Scale (BIS) total scores, BIS attention scores, and BIS nonplanning scores. Therefore, the right middle frontal gyrus is a critical region, when combined with BIS‐11, as a potential biomarker to identify the effect of abstinence with therapeutic intervention in methamphetamine (MA) individuals.
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