Differences in the amplitude of low-frequency fluctuation between methamphetamine and heroin use disorder individuals: A resting-state fMRI study.
Differences in the amplitude of low-frequency fluctuation between methamphetamine and heroin use disorder individuals: A resting-state fMRI study.
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甲基苯丙胺和海洛因使用障碍个体之间低频波动幅度的差异：静息态功能磁共振成像研究
DOI：
10.1002/brb3.1703
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发表时间：
2020-09
影响因子：
3.1
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Liu Y;Zhu J;Li Q;Wang Y;Li Y;Chen J;Dang S;Chen J;Shi H;Xue J;Li W;Wang W
甲基苯丙胺已超过海洛因成为中国最受欢迎的滥用药物。虽然海洛因和甲基苯丙胺的使用通过多巴胺通路的功能障碍导致使用障碍，但甲基苯丙胺滥用引起的精神障碍的发生率高于海洛因滥用引起的精神障碍的发生率。海洛因使用障碍（HUD）和甲基苯丙胺使用障碍（MAUD）之间的静息态功能差异以及静息态功能与MAUD相关精神障碍之间的关系尚不清楚。在本研究中，招募了21名男性MAUD患者，21名人口统计学匹配的HUD患者和21名正常对照（NC）。通过磁共振成像测量静息状态脑功能期间的低频波动（ALFF）幅度。通过症状自评量表（SCL-90）评估精神状态。与NC相比，MAUD患者的焦虑、偏执和其他项目的SCL 90评分增加，与HUD患者相比，敌意评分显著增加。HUD和NC个体之间无显著差异。与NC相比，MAUD患者丘脑、右中央后回和右颞下回的ALFF增加，但小脑的ALFF减少。HUD患者左侧额中回的ALFF显著高于NC患者，而左侧中央后回的ALFF显著低于NC患者。MAUD患者丘脑、右侧颞下回和双侧中央后回的ALFF显著高于HUD患者，小脑和左侧额叶中回的ALFF显著高于HUD患者。甲基苯丙胺可能比海洛因引起更严重的精神障碍。涉及情绪调节、听觉和记忆相关脑区的静息状态功能可能会影响与MAUD相关的精神病症状。甲基苯丙胺可能比海洛因引起更严重的精神障碍。涉及情绪调节、听觉和记忆相关脑区的静息状态功能可能会影响与甲基苯丙胺使用障碍相关的精神病症状。
Methamphetamine has surpassed heroin as the most popular abused drug in China. Although the use of both heroin and methamphetamine leads to use disorders through dysfunction of the dopamine pathway, the incidence of psychiatric disorder caused by methamphetamine abuse is higher than the incidence of psychiatric disorder caused by heroin abuse. The difference in resting‐state function between heroin use disorder (HUD) and methamphetamine use disorder (MAUD) and the relationship between resting‐state function and psychiatric disorder related to MAUD are unknown. In the present study, 21 male individuals with MAUD, 21 demographically matched individuals with HUD, and 21 normal controls (NC) were recruited. The amplitude of low‐frequency fluctuation (ALFF) during resting‐state brain function was measured by magnetic resonance imaging. Psychiatric status was evaluated by the Symptom Checklist‐90 (SCL90). Individuals with MAUD had increased SCL90 scores compared to those of the NC for anxiety, paranoia, and additional items, and the hostility score was significantly increased compared to that of individuals with HUD. There is no significant difference between HUD and NC individuals. Individuals with MAUD had increased ALFF compared to those of the NC for thalamus, right postcentral, and right inferior temporal gyri, but a decreased ALFF in the cerebellum. Individuals with HUD had significantly increased ALFF compared to those of the NC for left middle frontal gyrus but a decreased ALFF in the left postcentral gyrus. Individuals with MAUD had significantly increased ALFF compared to those of the HUD for thalamus, the right inferior temporal, and bilateral postcentral gyri, and the ALFF of cerebellum and left middle frontal was significantly increased. Methamphetamine can induce more serious psychiatric disorders than heroin. The resting‐state function involved in mood adjustment, the auditory, and memory‐related brain regions may affect psychotic symptoms related to MAUD. Methamphetamine can induce more serious psychiatric disorders than heroin. The resting‐state function involved in mood adjustment, auditory, and memory‐related brain regions may affect psychotic symptoms related to methamphetamine use disorder.
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影响因子：
3.4
作者：
Ipser, Jonathan C.;Uhlmann, Anne;Stein, Dan I.
通讯作者：
Stein, Dan I.
DOI：
10.5812/iranjradiol.14275
发表时间：
2014-05
期刊：
Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society
影响因子：
--
作者：
Alaee A;Zarghami M;Farnia S;Khademloo M;Khoddad T
通讯作者：
Khoddad T
DOI：
10.3969/j.issn.1002-0829.2012.05.004
发表时间：
2012-10
期刊：
Shanghai archives of psychiatry
影响因子：
--
作者：
Deng X;Huang Z;Li X;Li Y;Wang Y;Wu D;Gao B;Yang X
通讯作者：
Yang X
影响因子：
4.5
作者：
Kumari, Veena;Aasen, Ingrid;Sharma, Tonmoy
通讯作者：
Sharma, Tonmoy
影响因子：
4.5
作者：
Rusch, Nicolas;Spoletini, Ilaria;Spalletta, Gianfranco
通讯作者：
Spalletta, Gianfranco