Suppression of Somatosensory Evoked Cortical Responses by Noxious Stimuli
Suppression of Somatosensory Evoked Cortical Responses by Noxious Stimuli
复制标题
有害刺激对体感诱发皮质反应的抑制
DOI：
10.1007/s10548-019-00721-z
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发表时间：
2019
期刊：
影响因子：
2.7
通讯作者：
Makoto Nishihara
中科院分区：
文献类型：
--
作者：
Nobuyuki Takeuchi;Tomoaki Kinukawa;Shunsuke Sugiyama;Koji Inui;Kousuke Kanemoto;Makoto Nishihara
成对脉冲抑制是指对第二刺激的神经活动的衰减，在抑制冗余感觉输入中具有关键作用。先前的研究表明，皮层对躯体感觉刺激的反应不仅受到前一个相同刺激的调制，而且还受到来自不同亚模态的刺激的调制。使用脑磁图，我们研究了体感抑制引起的三种不同的条件刺激。测试刺激是以100 Hz持续1500 ms的一系列电脉冲到左手的背部。对于脉冲串，刺激的强度在1200 ms突然增加。记录皮质对强度突然变化的反应并用作测试反应。条件刺激以600 ms的纯音呈现，对右脚进行无害或有害的电刺激。使用四种刺激条件：（1）单独测试，（2）测试+听觉刺激，（3）测试+体感刺激，和（4）测试+伤害性刺激。我们的结果表明，与对条件（1）的反应相比，条件（3）和（4）在刺激侧对侧（cSII）和同侧（iSII）的次级躯体感觉皮层中的测试反应幅度显著较小，而初级躯体感觉皮层中的反应幅度在条件（3）和（4）之间没有差异。听觉刺激对躯体感觉变化相关反应无影响。这些结果表明，躯体感觉抑制不仅是由相同的躯体感觉亚模态和相同的皮肤部位的测试刺激的条件刺激，但也由不同的亚模态在偏远地区。
Paired-pulse suppression refers to attenuation of neural activity in response to a second stimulus and has a pivotal role in inhibition of redundant sensory inputs. Previous studies have suggested that cortical responses to a somatosensory stimulus are modulated not only by a preceding same stimulus, but also by stimulus from a different submodality. Using magnetoencephalography, we examined somatosensory suppression induced by three different conditioning stimuli. The test stimulus was a train of electrical pulses to the dorsum of the left hand at 100 Hz lasting 1500 ms. For the pulse train, the intensity of the stimulus was abruptly increased at 1200 ms. Cortical responses to the abrupt intensity change were recorded and used as the test response. Conditioning stimuli were presented at 600 ms as pure tones, either innocuous or noxious electrical stimulation to the right foot. Four stimulus conditions were used: (1) Test alone, (2) Test + auditory stimulus, (3) Test + somatosensory stimulus, and (4) Test + nociceptive stimulus. Our results showed that the amplitude of the test response was significantly smaller for conditions (3) and (4) in the secondary somatosensory cortex contralateral (cSII) and ipsilateral (iSII) to the stimulated side as compared to the response to condition (1), whereas the amplitude of the response in the primary somatosensory cortex did not differ among the conditions. The auditory stimulus did not have effects on somatosensory change-related response. These findings show that somatosensory suppression was induced by not only a conditioning stimulus of the same somatosensory submodality and the same cutaneous site to the test stimulus, but also by that of a different submodality in a remote area.
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影响因子：
2.5
作者：
BURTON, H;FABRI, M;ALLOWAY, K
通讯作者：
ALLOWAY, K
影响因子：
5.7
作者：
Nakagawa K;Inui K;Yuge L;Kakigi R
通讯作者：
Kakigi R
影响因子：
1.4
作者：
Becker, Jefferson;Filho, Irenio Gomes da Silva;Costa, Jaderson Costa da
通讯作者：
Costa, Jaderson Costa da
通过先前的正中神经、腓神经和听觉刺激来改变正中神经体诱发电位。
DOI：
--
发表时间：
1987
期刊：
Electroencephalography and Clinical Neurophysiology
影响因子：
--
作者：
P. Greenwood;Goff Wr
通讯作者：
Goff Wr
影响因子：
2.4
作者：
Inui K;Tsuruhara A;Kodaira M;Motomura E;Tanii H;Nishihara M;Keceli S;Kakigi R
通讯作者：
Kakigi R