The role of nutrition in Alzheimer's disease: epidemiological evidence.

The role of nutrition in Alzheimer's disease: epidemiological evidence.
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DOI:
10.1111/j.1468-1331.2009.02735.x
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发表时间:
2009-09
影响因子:
5.1
通讯作者:
Morris MC
Morris MC
中科院分区:
医学3区
文献类型:
--
作者:
Morris MC

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The prevalence of Alzheimer’s disease (AD) increases exponentially with age but there is limited knowledge of the modifiable risk factors for AD. However, there is growing evidence for possible dietary risk factors in the development of AD and cognitive decline with age, such as antioxidant nutrients, fish, dietary fats, and B-vitamins. Numerous animal and laboratory studies have shown that antioxidant nutrients can protect the brain from oxidative and inflammatory damage, but there are limited data available from epidemiological studies. There is more substantial epidemiological evidence from a number of recent studies that demonstrate a protective role of omega-3 fatty acids, such as docosahexaenoic acid, in AD and cognitive decline. This review will focus on epidemiological evidence investigating the relationship between nutrition and AD, focusing particularly on the roles of dietary fats and antioxidants.
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