Pulmonary comorbidities in psoriasis are associated with a high risk of respiratory failure.
Pulmonary comorbidities in psoriasis are associated with a high risk of respiratory failure.
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DOI：
10.1177/03000605231182881
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发表时间：
2023-06
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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确定银屑病患者发生呼吸衰竭高风险相关的呼吸合并症。这是一项对英国生物银行队列受试者数据的横断面分析。所有诊断均为自我报告。通过调整年龄、性别、体重、糖尿病和吸烟史等因素后的logistic回归模型比较各呼吸道合并症的风险；还比较了每种肺部合并症并发呼吸衰竭的风险。在数据库中的472,782名高加索受试者中，有3,285人自我报告诊断为牛皮癣。与非银屑病受试者相比，更多的男性和吸烟者报告患有银屑病，年龄较大，体重和体重指数较高，肺功能较低。与没有牛皮癣的人相比，患有牛皮癣的人患多种肺部合并症的风险明显更高。此外，与非银屑病患者相比，银屑病患者出现呼吸衰竭、哮喘和气流受限的风险更高。伴有银屑病和肺部合并症（如哮喘和气流受限）的受试者发生呼吸衰竭的风险增加。常见的免疫病理联系暗示“皮肤-肺轴”可能是银屑病和肺部合并症的基础。
To identify respiratory comorbidities associated with a high risk of developing respiratory failure in subjects with psoriasis. This was a cross-sectional analysis of data from subjects enrolled in the UK Biobank cohort. All diagnoses were self-reported. The risk of each respiratory comorbidity was compared by logistic regression models adjusting for age, sex, weight, diabetes mellitus, and smoking history; the risk of comorbid respiratory failure for each pulmonary comorbidity was also compared. Of the 472,782 Caucasian subjects in the database, 3,285 self-reported a diagnosis of psoriasis. More men and smokers reported psoriasis and were older, had higher weight and body mass index, and lower pulmonary function than non-psoriatic subjects. Those with psoriasis were at significantly higher risk for multiple pulmonary comorbidities compared to those without psoriasis. Furthermore, those with psoriasis had a higher risk for respiratory failure accompanied by asthma and airflow limitation than non-psoriatic subjects. Subjects with psoriasis and pulmonary comorbidities, such as asthma and airflow limitation, are at increased risk for respiratory failure. Common immunopathological links implicating a ‘skin-lung axis’ may underlie psoriasis and pulmonary comorbidities.
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影响因子：
30.8
作者：
Nair RP;Duffin KC;Helms C;Ding J;Stuart PE;Goldgar D;Gudjonsson JE;Li Y;Tejasvi T;Feng BJ;Ruether A;Schreiber S;Weichenthal M;Gladman D;Rahman P;Schrodi SJ;Prahalad S;Guthery SL;Fischer J;Liao W;Kwok PY;Menter A;Lathrop GM;Wise CA;Begovich AB;Voorhees JJ;Elder JT;Krueger GG;Bowcock AM;Abecasis GR;Collaborative Association Study of Psoriasis
通讯作者：
Collaborative Association Study of Psoriasis
影响因子：
1.6
作者：
Gupta, Rashmi;Debbaneh, Maya G;Liao, Wilson
通讯作者：
Liao, Wilson
影响因子：
7
作者：
Hudey SN;Ledford DK;Cardet JC
通讯作者：
Cardet JC
DOI：
10.1016/j.mayocpiqo.2018.07.006
发表时间：
2018-12-01
期刊：
Mayo Clinic proceedings. Innovations, quality & outcomes
影响因子：
--
作者：
Kawamoto, Hironori;Hara, Hiromichi;Kuwano, Kazuyoshi
通讯作者：
Kuwano, Kazuyoshi
影响因子：
5.8
作者：
Nadeem, Ahmed;Al-Harbi, Naif O.;Ahmad, Sheikh F.
通讯作者：
Ahmad, Sheikh F.