Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin.
Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin.
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人乳头瘤病毒疫苗和百日咳毒素联合给药后，小鼠下丘脑遭到破坏，血管细胞凋亡。
DOI：
10.1038/srep36943
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发表时间：
2016-11-11
影响因子：
4.6
通讯作者：
Nakajima T
中科院分区：
文献类型：
--
作者：
Aratani S;Fujita H;Kuroiwa Y;Usui C;Yokota S;Nakamura I;Nishioka K;Nakajima T
接种疫苗是预防人类感染包括病毒在内的传染病的最有效方法。在人乳头瘤病毒（HPV）疫苗的情况下，一个意想不到的新疾病实体，HPV疫苗接种相关的神经免疫病综合征（HANS），已被报道，仍有待仔细核实。为了阐明HANS的机制，我们采用了一种类似于主动实验性自身免疫性脑炎（EAE）模型的策略，该模型是用于诱导中枢神经系统最大免疫学变化的最流行的动物模型之一。令人惊讶的是，用百日咳毒素接种的小鼠显示出神经学表型，包括尾部反射和运动机动性的低反应性。病理学分析显示，下丘脑和第三脑室周围的室周区域的损害，这些区域含有凋亡的血管内皮细胞。这些数据表明，对HPV疫苗易感的HPV疫苗接种者可能在某些环境因素下发生HANS。这些结果将使我们对HANS的小鼠病理模型有新的认识，并有助于我们找到治疗HANS患者的方法。
Vaccination is the most powerful way to prevent human beings from contracting infectious diseases including viruses. In the case of the human papillomavirus (HPV) vaccine, an unexpectedly novel disease entity, HPV vaccination associated neuro-immunopathetic syndrome (HANS), has been reported and remains to be carefully verified. To elucidate the mechanism of HANS, we applied a strategy similar to the active experimental autoimmune encephalitis (EAE) model - one of the most popular animal models used to induce maximum immunological change in the central nervous system. Surprisingly, mice vaccinated with pertussis toxin showed neurological phenotypes that include low responsiveness of the tail reflex and locomotive mobility. Pathological analyses revealed the damage to the hypothalamus and circumventricular regions around the third ventricle, and these regions contained apoptotic vascular endothelial cells. These data suggested that HPV-vaccinated donners that are susceptible to the HPV vaccine might develop HANS under certain environmental factors. These results will give us the new insight into the murine pathological model of HANS and help us to find a way to treat of patients suffering from HANS.
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3.3
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