Breastmilk from allergic mothers can protect offspring from allergic airway inflammation.
Breastmilk from allergic mothers can protect offspring from allergic airway inflammation.
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DOI：
10.1089/bfm.2008.0130
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Puddington L
中科院分区：
文献类型：
--
作者：
Matson AP;Thrall RS;Rafti E;Puddington L
母乳喂养与降低儿童患哮喘的风险有关。使用小鼠模型，我们以前证明，与Th 1型免疫卵清蛋白（OVA）的母亲转移抗原特异性保护，从卵清蛋白诱导的过敏性气道疾病（AAD）到他们的后代。本研究的目的是评估母乳和过敏母亲的B细胞免疫在抗抗AD垂直传播中的作用。这是使用收养护理策略进行调查。幼稚的后代由过敏性野生型或B细胞缺陷的养母喂养，养母具有对OVA的Th 2型免疫史。断奶后，用OVA-Al（OH）3免疫后代，并用雾化卵蛋白激发以诱导AAD。野生型卵清蛋白免疫的养母养育的后代表现出较低水平的卵清蛋白特异性免疫球蛋白E，白细胞介素-5，和气道嗜酸性粒细胞比幼稚对照母亲养育的后代。相比之下，由B细胞缺陷的OVA免疫养母养育的后代具有与由幼稚对照母亲养育的后代相似的OVA诱导的AAD参数。这些数据表明，过敏母亲的母乳保护后代免受AAD的能力依赖于完整的母体B细胞免疫。单独哺乳，当由野生型AAD母亲进行时，足以使后代从母乳中获得抗原特异性保护因子。
Breastfeeding is associated with a reduced risk of developing asthma in children. Using a murine model we previously demonstrated that mothers with Th1-type immunity to ovalbumin (OVA) transfer antigen-specific protection from OVA-induced allergic airway disease (AAD) to their offspring. The aim of this study was to evaluate the contribution of breastmilk and maternal B cell immunity from allergic mothers in the vertical transmission of protection from AAD. This was investigated using an adoptive nursing strategy. Naive offspring were nursed by allergic wild-type or B cell-deficient foster mothers with histories of Th2-type immunity to OVA. Following weaning, offspring were immunized with OVA-Al(OH)3 and challenged with aerosolized OVA to induce AAD. Offspring nursed by wild-type OVA-immune foster mothers demonstrated lower levels of OVA-specific immunoglobulin E, interleukin-5, and airway eosinophilia than progeny nursed by naive control mothers. In contrast, offspring nursed by B cell-deficient OVA-immune foster mothers had similar parameters of OVA-induced AAD as progeny nursed by naive control mothers. These data demonstrate the ability of breastmilk from allergic mothers to protect offspring from AAD was dependent on intact maternal B cell immunity. Nursing alone, when done by wild-type mothers with AAD, was sufficient for offspring to acquire the antigen-specific protective factor(s) from breastmilk.
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影响因子：
4.4
作者：
Matson, Adam P.;Zhu, Li;Puddington, Lynn
通讯作者：
Puddington, Lynn
影响因子：
15.9
作者：
Oshiba, A;Hamelmann, E;Gelfand, EW
通讯作者：
Gelfand, EW
DOI：
10.1084/jem.185.5.885
发表时间：
1997-03-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Korsgren M;Erjefält JS;Korsgren O;Sundler F;Persson CG
通讯作者：
Persson CG
影响因子：
5.1
作者：
ALBRECHT, P;ENNIS, FA;KRUGMAN, S
通讯作者：
KRUGMAN, S
DOI：
10.1165/ajrcmb.20.3.3291
发表时间：
1999-03-01
影响因子：
6.4
作者：
MacLean, JA;Sauty, A;De Sanctis, GT
通讯作者：
De Sanctis, GT