Quantitative magnetic resonance imaging and neuropsychological functions in dementia of the Alzheimer type
Quantitative magnetic resonance imaging and neuropsychological functions in dementia of the Alzheimer type
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阿尔茨海默型痴呆的定量磁共振成像和神经心理学功能
DOI：
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发表时间：
1997
影响因子：
6.9
通讯作者：
Heinrich Sauer
中科院分区：
文献类型：
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作者：
J. Pantel;J. Schröder;L. Schad;M. Friedlinger;M. V. Knopp;R. Schmitt;M. Geissler;Stefan Blüml;M. Essig;Heinrich Sauer
背景本研究的目的是探讨阿尔茨海默型痴呆（DAT）的神经心理功能方面的形态学变化，揭示了定量磁共振成像（MRI）。方法. 20例DAT患者（NINCDS-ADRDA标准）和10例年龄和性别匹配的健康对照。神经心理学功能的测试组合，包括痴呆的严重程度，语言和视觉记忆，集中和注意力，语言技能和一般智力以及日常生活活动进行了评估。使用1.5T Siemens磁共振成像仪采集3D MRI序列。采用NMRWin软件计算全脑体积、颅内总体积（TIV）、额叶和颞叶体积以及杏仁核海马复合体（AHC）体积。结果除TIV外，诊断组之间的所有形态测量参数均存在显著差异。AHC卷区分组之间最好的，只有一个小的重叠。AHC萎缩超过全身萎缩。将DAT患者分为轻度和中度受累组后重新分析数据时，这些发现得到了证实。痴呆的严重程度与AHC体积和双侧颞叶体积显著相关，但与全脑体积和额叶体积无关。结论.这些结果强调了重要的作用的时间亚结构的病因学和DAT的进展。他们表明，AHC的体积可以通过MRI监测，并可用于跟踪疾病的过程。
Background. The aim of the present study was to investigate neuropsychological functions in dementia of the Alzheimer type (DAT) with respect to morphological changes that were revealed by quantitative magnetic resonance imaging (MRI). Methods. Twenty patients with DAT (NINCDS-ADRDA criteria) and 10 healthy age and sex matched controls were included. The neuropsychological function was evaluated on a test battery covering the severity of dementia, verbal and visual memory, concentration and attention, language skills and general intelligence as well as activities of daily living. 3D MRI sequences were acquired using a 1.5 T Siemens MAGNETOM. Whole brain volume, total intracranial volume (TIV), volume of the frontal and temporal lobes and volumes of the amygdalahippocampus complex (AHC) were assessed using the newly developed software NMRWin. Results. Apart from TIV all morphometric parameters differed significantly between the diagnostic groups. AHC volumes discriminated best between the groups, with only a small overlap. AHC atrophy exceeded generalized atrophy. These findings were confirmed when the data were reanalysed after dividing the DAT patients into a mildly and moderately affected group. The severity of dementia was significantly correlated with the volumes of the AHC and the volumes of the temporal lobes bilaterally, but not with the whole brain volume and the volumes of the frontal lobes. Conclusions. These results underline the important role of the temporal substructures for aetiology and progression of DAT. They indicate that the volume of the AHC can be monitored by MRI and may be used to follow up the disease process.
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阿尔茨海默病中内侧颞叶体积、局部脑血流量和认知的定量变化。
影响因子：
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作者：
Pearlson,GD;Harris,GJ;Powers,RE;Barta,PE;Camargo,EE;Chase,GA;Noga,JT;Tune,LE
通讯作者：
Tune,LE
影响因子：
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作者：
B. Reisberg;S. Ferris
通讯作者：
B. Reisberg;S. Ferris
影响因子：
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作者：
GOLOMB, J;DELEON, MJ;FERRIS, SH
通讯作者：
FERRIS, SH
影响因子：
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作者：
KILLIANY, RJ;MOSS, MB;JOLESZ, F
通讯作者：
JOLESZ, F