Induced neuronal cells: how to make and define a neuron.
Induced neuronal cells: how to make and define a neuron.
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DOI:
10.1016/j.stem.2011.11.015
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发表时间:
2011-12-02
期刊:
影响因子:
23.9
通讯作者:
Wernig, Marius
中科院分区:
文献类型:
--
作者:
Yang, Nan;Ng, Yi Han;Pang, Zhiping P.;Suedhof, Thomas C.;Wernig, Marius
Cellular plasticity is a major focus of investigation in developmental biology. The recent discovery that induced neuronal (iN) cells can be generated from mouse and human fibroblasts by expression of defined transcription factors suggested that cell fate plasticity is much wider than previously anticipated. In this review, we summarize the most recent developments of this nascent field and suggest criteria helping to define and categorize iN cells given the complexity of the neuronal identity.
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