ALTERATIONS IN NEUROBEHAVIORAL RESPONSES IN FISHES EXPOSED TO LEAD AND LEAD-CHELATING AGENTS
ALTERATIONS IN NEUROBEHAVIORAL RESPONSES IN FISHES EXPOSED TO LEAD AND LEAD-CHELATING AGENTS
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暴露于铅和铅螯合剂的鱼类神经行为反应的变化
DOI：
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
R. Steinpreis
中科院分区：
文献类型：
--
作者：
D. Weber;W. Dingel;J. Panos;R. Steinpreis
概要。铅（Pb）是一种神经毒性元素，在暴露于亚致死浓度的几天内会导致鱼类行为障碍。要测试的假设，铅的内部存储有长期的行为影响，铅暴露（0.3 ppm）的鱼，无论是处理与铅螯合药物meso-2，3二巯基丁二酸（DMSA）或返回到控制条件（0.0 ppm铅）。游泳能力在DMSA（1.5ppm）暴露7天后改善（ANOVA P 0.0ppm水-2周后488.8 ± 67.3ppm; Pb暴露-> 1.5ppm DMSA-2周后202.0 ± 116.0ppm。而去除铅并不促进恢复到对照值，添加DMSA可以（ANOVA，P < 0.05）。在铅暴露（0.1 ppm）和铅暴露-> 0.0 ppm铅水组中，对刺激的时空反应模式与对照组（0.0 ppm铅; 0.0 ppm DMSA）的刺激反应角度、远离刺激源的运动速率和程度不同。虽然这两种控制类型是相似的刺激反应角度和反应时间，DMSA只控制，不像0.0 ppm铅控制，没有响应作为一个紧密相关的组后，刺激。
SYNOPSIS. Lead (Pb) is a neurotoxic element that causes behavioral dysfunction in fishes within days of exposure to sublethal concentrations. To test the hypothesis that internal stores of Pb have long-term behavioral effects, Pb-exposed (0.3 ppm) fish were either treated with the Pb-chelating drug meso-2,3 dimercaptosuccinic acid (DMSA) or returned to control conditions (0.0 ppm Pb). Swimming capacity improved after a 7-day DMSA (1.5 ppm) exposure (ANOVA P 0.0 ppm water—488.8 ± 67.3 ppm after 2 wks; Pb-exposed —> 1.5 ppm DMSA—202.0 ± 116.0 ppm after 2 wks. Norepinephrine and vanillylmandelic acid levels were altered by Pb exposure (ANOVA, P < 0.05). Whereas removing Pb did not facilitate a return to control values, adding DMSA did (ANOVA, P < 0.05). Temporal-spatial response patterns to a stimulus in Pb-exposed (0.1 ppm) and Pb-exposed —» 0.0 ppm Pb water groups differed from controls (0.0 ppm Pb; 0.0 ppm DMSA) for stimulus response angle, and rate and extent of movement away from stimulus source. While the two control types were similar for stimulus response angle and reaction time, DMSA-only controls, unlike 0.0 ppm Pb controls, did not respond as a tightly-associated group after the stimulus.
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DMSA 螯合疗法过程中铅的动员和长期疗效。
DOI：
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发表时间：
1988
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Cory-Slechta,DA
通讯作者：
Cory-Slechta,DA
影响因子：
10.4
作者：
Todd AC;Wetmur JG;Moline JM;Godbold JH;Levin SM;Landrigan PJ
通讯作者：
Landrigan PJ
影响因子：
3.5
作者：
Frumkin,H;Gerr,F
通讯作者：
Gerr,F
影响因子：
1.7
作者：
EATON, RC;DIDOMENICO, R;NISSANOV, J
通讯作者：
NISSANOV, J
丙烯酰胺对虹鳟鱼的行为和组织学影响。
影响因子：
3.8
作者：
Petersen,DW;Cooper,KR;Friedman,MA;Lech,JJ
通讯作者：
Lech,JJ