Circulating microRNAs and Bioinformatics Tools to Discover Novel Diagnostic Biomarkers of Pediatric Diseases.
Circulating microRNAs and Bioinformatics Tools to Discover Novel Diagnostic Biomarkers of Pediatric Diseases.
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DOI：
10.3390/genes8090234
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发表时间：
2017-09-19
期刊：
影响因子：
3.5
通讯作者：
Masotti A
中科院分区：
文献类型：
--
作者：
Baldassarre A;Felli C;Prantera G;Masotti A
MicroRNAs （miRNAs）是一种小的非编码rna，在转录后水平调控基因表达。目前的研究表明，mirna也存在于细胞外空间，被包装成各种膜结合囊泡，或与rna结合蛋白相关。循环mirna是高度稳定的，可以作为细胞间信使影响许多生理过程。体液中循环的microrna作为临床生物标志物的潜在用途引起了人们的强烈兴趣。事实上，它们显著的稳定性和相对容易检测使循环mirna成为快速和非侵入性诊断的理想工具。本文综述了最近关于细胞外mirna的起源、功能和诊断潜力的见解，特别关注儿科疾病，以探索非侵入性儿科诊断的替代采样来源的可行性。我们还将讨论用于循环mirna的特定生物信息学工具和数据库，重点是识别和发现儿科疾病的新型诊断生物标志物。
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Current studies have shown that miRNAs are also present in extracellular spaces, packaged into various membrane-bound vesicles, or associated with RNA-binding proteins. Circulating miRNAs are highly stable and can act as intercellular messengers to affect many physiological processes. MicroRNAs circulating in body fluids have generated strong interest in their potential use as clinical biomarkers. In fact, their remarkable stability and the relative ease of detection make circulating miRNAs ideal tools for rapid and non-invasive diagnosis. This review summarizes recent insights about the origin, functions and diagnostic potential of extracellular miRNAs by especially focusing on pediatric diseases in order to explore the feasibility of alternative sampling sources for the development of non-invasive pediatric diagnostics. We will also discuss specific bioinformatics tools and databases for circulating miRNAs focused on the identification and discovery of novel diagnostic biomarkers of pediatric diseases.
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