Juxtacrine intercellular signaling: another way to do it.
Juxtacrine intercellular signaling: another way to do it.
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近分泌细胞间信号传导：另一种方法。
DOI：
10.1165/ajrcmb/9.6.573
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发表时间：
1993
影响因子：
6.4
通讯作者：
Prescott,SM
中科院分区：
文献类型：
--
作者：
Zimmerman,GA;Lorant,DE;McIntyre,TM;Prescott,SM
细胞间相互作用，其中一个细胞向另一个细胞发送信号，诱导第二个细胞功能的变化，在肺和其他器官的形态发生，发育，炎症和修复中很常见。在阿曲他克林细胞间信号传导中，诱导靶细胞功能变化的分子保持与信号传导细胞的质膜结合，而不是在流体相中起作用。这一特征将肾上腺素信号传导与内分泌和旁分泌刺激区分开来，并提供了一种严格的空间控制一个细胞激活另一个细胞的机制。邻他克林信号可能在需要严格调节的生理事件中很常见，并且邻他克林信号的破坏可能导致病理结果。在这篇简短的综述中，讨论了阿曲他克林信号传导的一般原理以及几个具体的例子。一些细胞表达的分子通过将信号传递给其他细胞而起作用（1）。生长因子、趋化因子和激素是信号分子的实例。单细胞生物，如假单胞菌的某些菌株，似乎通过扩散信号分子相互作用;这可能有助于它们的毒力（2）。多细胞生物也会产生这些因子。信号分子在生物系统中的应用，如单个细菌和后生动物细胞组成的复杂组织，表明这种特性具有显著的优势。由一个细胞合成的信号分子将其信息传递到哺乳动物组织中的靶细胞或一组靶细胞的传统机制为研究人员和临床医生所熟知（3）。在内分泌系统中，信号传导因子从原始细胞释放，并由血液或其他液体携带到远处，在那里它与应答细胞质膜上的信号转导受体结合，并在细胞膜上产生信号。导致其功能发生变化。这是蛋白质或多肽激素的经典作用机制。释放到液相中的信号分子也可以在局部环境中以更短的距离作用于靶细胞;这被称为细胞间相互作用的旁分泌机制（3）。信号分子可以作用于起源细胞，这是细胞活化的自分泌机制
Intercellular interactions in which one cell sends a signal to another cell, inducing a change in function of the second cell, are common in morphogenesis, development, inflammation, and repair of the lung and other organs. In juxtacrine intercellular signaling, the molecule that induces the functional changes in the target cell remains associated with the plasma membrane of the signaling cell, rather than acting in the fluid phase. This feature distinguishes juxtacrine signaling from endocrine and paracrine stimulation and provides a mechanism for strict spatial control of activation of one cell by another. Juxtacrine signaling is likely to be common in physiologic events that require tight regulation, and disruption of juxtacrine signaling may lead to pathologic outcomes. Inthis minireview, general principles as well as several specific examples of juxtacrine signaling are discussed.Some molecules expressed by cells act by transmitting signals to other cells (1). Growth factors, chemotactic factors, and hormones are examples of signaling molecules. Singlecell organisms, such as certain strains of Pseudomonas, appear to interact via diffusible signaling molecules; this may contribute to their virulence (2). Multicellular organisms also produce such factors. The use of signaling molecules by biologic systems as diverse as populations of single bacteria and metazoan cells organized into complex tissues indicates that this property confers significant advantages. The traditional mechanisms by which a signaling molecule synthesized by one cell gets its message to a target cell or a group of target cells in mammalian tissues are well known to investigators and clinicians alike (3). In endocrine systems, the signaling factor is released from the cell of origin and is carried by the blood or another fluid to a distant site, where it binds to a signal-transducing receptor on the plasma membrane of the responding cell and. induces a change in its function. This is the classic mechanism of action of a protein or polypeptide hormone. Signaling molecules that are released into the fluid phase may also act on target cells over much shorter distances, in a local environment; this is termed a paracrine mechanism of intercellular interaction (3). Signaling molecules may act back on the cells of origin, an autocrine mechanism of cellular activation
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
Zimmerman,GA;Hill,HR
通讯作者：
Hill,HR