An approach to studying the neural correlates of reserve.

An approach to studying the neural correlates of reserve.
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DOI:
10.1007/s11682-016-9566-x
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发表时间:
2017-04
影响因子:
3.2
通讯作者:
Stern Y
Stern Y
中科院分区:
医学3区
文献类型:
--
作者:
Stern Y

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本文的目的是回顾我目前对认知储备(CR)、大脑储备和大脑维护概念的理解,并描述我们小组使用成像研究其神经基础的方法。我提出了一个工作模型,利用有关大脑完整性、临床状态、认知激活和 CR 代理的数据来开发分析,以探索认知储备和大脑维护的神经基础。基本模型假设大脑变化对认知的影响是由任务相关激活介导的。我们将 CR 视为调节因子,以了解任务相关激活如何作为 CR 的函数而变化,或者 CR 如何独立于任务相关激活的这些差异而运作。我希望本次演讲能够引发研究这些概念的小组之间的讨论,使我们能够就定义、方法论和途径达成一些共识。
The goal of this paper is to review my current understanding of the concepts of cognitive reserve (CR), brain reserve and brain maintenance, and to describe our group’s approach to using imaging to study their neural basis. I present a working model for utilizing data regarding brain integrity, clinical status, cognitive activation and CR proxies to develop analyses that can explore the neural basis of cognitive reserve and brain maintenance. The basic model assumes that the effect of brain changes on cognition is mediated by task-related activation. We treat CR as a moderator to understand how task-related activation might vary as a function of CR, or how CR might operate independently of these differences in task-related activation. My hope is that this presentation will spark discussion across groups that study these concepts, allowing us to come to some common agreement on definitions, methodology and approaches.
DOI: 10.1016/j.neuropsychologia.2012.09.039
发表时间: 2012-12
期刊: Neuropsychologia
影响因子: 2.6
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