Age differences of multivariate network expressions during task-switching and their associations with behavior.
Age differences of multivariate network expressions during task-switching and their associations with behavior.
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DOI：
10.1016/j.neuropsychologia.2012.09.039
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发表时间：
2012-12
期刊：
影响因子：
2.6
通讯作者：
Stern Y
中科院分区：
文献类型：
--
作者：
Gazes Y;Rakitin BC;Habeck C;Steffener J;Stern Y
采用功能磁共振成像（fMRI）技术对24名青年（25.2±2.73岁）和23名老年人（65.2±2.65岁）的任务转换相关功能网络激活的影响进行了研究。研究目标是：(1)确定年轻人和老年人共享的网络，(2)确定每个年龄组的其他网络，(3)检查所确定的网络与任务转换行为表现之间的关系。采用有序趋势协方差分析方法对网络进行识别，利用任务需求越大激活越强的优势，隔离由任务切换所招募的区域网络。我们发现了两个与任务相关的网络：一个是年轻人和老年人都强烈表达的共享网络，另一个是在共享网络中剩余的年轻人数据中确定的网络。在之前的研究中，这两个网络都由与任务转换相关的区域组成，包括额叶中回、中央前回、前扣带和顶叶上小叶。在两个年龄组中，共享网络的模式表达不仅与反应时间有关，而且不同任务条件下模式表达的差异（任务切换减去单任务）也与不同任务条件下RT的差异相关。相反，年轻残留网络的表达表现出较大的年龄效应，老年人不会像年轻人那样增加任务需求更大的网络表达，并且表达与准确性之间的相关性仅在年轻人中显著。因此，尽管与RT相关的网络在老年人中得以保留，但与准确性相关的另一个网络却被破坏了。
The effect of aging on functional network activation associated with task-switching was examined in 24 young (age = 25.2 ± 2.73 years) and 23 older adults (age = 65.2 ± 2.65 years) using functional Magnetic Resonance Imaging (fMRI). The study goals were to (1) identify a network shared by both young and older adults, (2) identify additional networks in each age group, and (3) examine the relationship between the networks identified and behavioral performance in task-switching. Ordinal Trend Covariance Analysis was used to identify the networks, which takes advantage of increasing activation with greater task demand to isolate the network of regions recruited by task-switching. Two task-related networks were found: a shared network that was strongly expressed by both young and older adults and a second network identified in the young data that was residualized from the shared network. Both networks consisted of regions associated with task-switching in previous studies including the middle frontal gyrus, the precentral gyrus, the anterior cingulate, and the superior parietal lobule. Not only was pattern expression of the shared network associated with reaction time in both age groups, the difference in the pattern expression across task conditions (task-switch minus single-task) was also correlated with the difference in RT across task conditions. On the contrary, expression of the young residual network showed a large age effect such that older adults do not increase expression of the network with greater task demand as young adults do and correlation between expression and accuracy was significant only for young adults. Thus, while a network related to RT is preserved in older adults, a different network related to accuracy is disrupted.
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影响因子：
5.8
作者：
Lustig, Cindy;Shah, Priti;Seidler, Rachael;Reuter-Lorenz, Patricia A.
通讯作者：
Reuter-Lorenz, Patricia A.
影响因子：
5.7
作者：
Madden, David J.;Costello, Matthew C.;Dennis, Nancy A.;Davis, Simon W.;Shepler, Anne M.;Spaniol, Julia;Bucur, Barbara;Cabeza, Roberto
通讯作者：
Cabeza, Roberto
DOI：
10.1016/j.cogbrainres.2004.10.010
发表时间：
2005-05-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Habeck, C;Rakitin, BC;Stern, Y
通讯作者：
Stern, Y
影响因子：
1.8
作者：
Kramer, AF;Hahn, S;Gopher, D
通讯作者：
Gopher, D
影响因子：
3.8
作者：
Karayanidis F;Whitson LR;Heathcote A;Michie PT
通讯作者：
Michie PT