Association between serum Klotho concentration and hyperlipidemia in adults: a cross-sectional study from NHANES 2007-2016.
Association between serum Klotho concentration and hyperlipidemia in adults: a cross-sectional study from NHANES 2007-2016.
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DOI：
10.3389/fendo.2023.1280873
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
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Klotho蛋白是一种有充分证据的抗衰老蛋白，以其多种生物学功能而闻名。高脂血症是各种慢性病的独立危险因素。然而，对Klotho和高脂血症之间的联系的了解有限。目的是评估血清Klotho水平与成人高脂血症之间的关系。这项研究包括2006年至2017年NHANES数据库中的11,618人。高脂血症是根据国家胆固醇教育计划指南进行诊断的。用酶联免疫吸附测定试剂盒检测血清Klotho浓度，用多变量Logistic回归模型评价Klotho与高脂血症的关系。用拟合的平滑曲线和阈值效应分析来描述非线性关系。在我们的多元Logistic回归模型中，在调整综合混杂因素后，血清Klotho浓度与高脂血症显著相关(每标准差增量优势比(OR)：0.91；95%可信区间(CI)：0.86-0.97)。与Klotho四分位数最低的个体相比，Klotho四分位数最高的个体高脂血症患病率显著降低(OR：0.72；95%CI：0.58-0.90)。使用两段Logistic回归模型，我们发现血清Klotho浓度与高脂血症之间呈U型关系，拐点为1,365.5pg/ml。亚组分析没有显示任何潜在的缓和效应。这项研究揭示了Klotho水平和高脂血症之间的负相关关系。血清Klotho与高脂血症之间的潜在机制有待进一步研究。
The Klotho protein is a well-documented anti-aging protein known for its diverse biological functions. Hyperlipidemia is an established independent risk factor for various chronic diseases. However, there is limited understanding of the connection between Klotho and hyperlipidemia. The aim was to assess the association between serum Klotho levels and hyperlipidemia among adults. The study included 11,618 individuals from the NHANES database from 2006 to 2017. Hyperlipidemia was diagnosed following the National Cholesterol Education Program guidelines. Serum Klotho concentration was measured by an enzyme-linked immunosorbent assay kit, and the association between Klotho and hyperlipidemia was assessed by a multivariable logistic regression model. Fitted smoothing curves and threshold-effect analysis were employed to describe nonlinear relationships. In our multiple logistic regression models, serum Klotho concentration was significantly associated with hyperlipidemia after adjusting for comprehensive confounders (per SD increment odds ratio (OR): 0.91; 95% confidence interval (CI): 0.86–0.97). Compared to individuals in the lowest Klotho quartile, those in the highest quartile exhibited a substantially decreased prevalence of hyperlipidemia (OR: 0.72; 95% CI: 0.58–0.90). Using a two-segment logistic regression model, we identified a U-shaped relationship between serum Klotho concentration and hyperlipidemia, with an inflection point at 1,365.5 pg/mL. Subgroup analysis did not reveal any potential moderating effects. This study revealed an inverse relationship between Klotho levels and hyperlipidemia. Further investigation is warranted to explore the underlying mechanism between serum Klotho and hyperlipidemia.
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影响因子：
5.2
作者：
通讯作者：
--
影响因子：
8.1
作者：
Landry T;Li P;Shookster D;Jiang Z;Li H;Laing BT;Bunner W;Langton T;Tong Q;Huang H
通讯作者：
Huang H
DOI：
10.1093/gerona/63.5.447
发表时间：
2008-05-01
影响因子：
5.1
作者：
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通讯作者：
Barzilai, Nir
影响因子：
7.2
作者：
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通讯作者：
Tesone, C
影响因子：
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作者：
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通讯作者：
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