Astrocytes at the Hub of the Stress Response: Potential Modulation of Neurogenesis by miRNAs in Astrocyte-Derived Exosomes.
Astrocytes at the Hub of the Stress Response: Potential Modulation of Neurogenesis by miRNAs in Astrocyte-Derived Exosomes.
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星形胶质细胞处于应激反应的中心：星形胶质细胞衍生的外泌体中 miRNA 对神经发生的潜在调节。
DOI：
10.1155/2017/1719050
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发表时间：
2017
影响因子：
4.3
通讯作者：
Henzi R
中科院分区：
文献类型：
--
作者：
Luarte A;Cisternas P;Caviedes A;Batiz LF;Lafourcade C;Wyneken U;Henzi R
重复性压力会对大脑功能和神经网络产生负面影响。此外，成人神经发生在慢性应激模型和相关的人类疾病（如单相抑郁症和双相情感障碍）中持续受损，而通过有效的抗抑郁治疗可以恢复。成体神经原性小生境除了扩增祖细胞、成神经细胞、未成熟和成熟神经元、周细胞、星形胶质细胞和小胶质细胞之外还含有神经祖细胞。由于星形胶质细胞的特殊和关键位置，其末端足包裹内皮细胞，并与龛内细胞密切联系，星形胶质细胞可能构成一个节点，将外周血中的全身应激信号（如糖皮质激素）连接到参与神经发生过程的细胞。已经提出星形胶质细胞和龛细胞之间的通信依赖于直接的细胞-细胞接触和可溶性介质。此外，新的证据表明，这种通信可能是由细胞外囊泡如外来体介导的，特别是通过它们的miRNA货物。在这里，我们解决了一些最新的发现，关于压力的影响，在生物学的神经原性生态位，并假设如何星形胶质细胞外泌体（和miRNA）可能在这种现象中发挥了重要作用。
Repetitive stress negatively affects several brain functions and neuronal networks. Moreover, adult neurogenesis is consistently impaired in chronic stress models and in associated human diseases such as unipolar depression and bipolar disorder, while it is restored by effective antidepressant treatments. The adult neurogenic niche contains neural progenitor cells in addition to amplifying progenitors, neuroblasts, immature and mature neurons, pericytes, astrocytes, and microglial cells. Because of their particular and crucial position, with their end feet enwrapping endothelial cells and their close communication with the cells of the niche, astrocytes might constitute a nodal point to bridge or transduce systemic stress signals from peripheral blood, such as glucocorticoids, to the cells involved in the neurogenic process. It has been proposed that communication between astrocytes and niche cells depends on direct cell-cell contacts and soluble mediators. In addition, new evidence suggests that this communication might be mediated by extracellular vesicles such as exosomes, and in particular, by their miRNA cargo. Here, we address some of the latest findings regarding the impact of stress in the biology of the neurogenic niche, and postulate how astrocytic exosomes (and miRNAs) may play a fundamental role in such phenomenon.
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DOI：
10.1523/jneurosci.0558-12.2012
发表时间：
2012-06-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Åkerblom M;Sachdeva R;Barde I;Verp S;Gentner B;Trono D;Jakobsson J
通讯作者：
Jakobsson J
影响因子：
64.5
作者：
Bonaguidi MA;Wheeler MA;Shapiro JS;Stadel RP;Sun GJ;Ming GL;Song H
通讯作者：
Song H
影响因子：
5.3
作者：
Brites D;Fernandes A
通讯作者：
Fernandes A
影响因子：
11.4
作者：
Bianco, Fabio;Perrotta, Cristiana;Novellino, Luisa;Francolini, Maura;Riganti, Loredana;Menna, Elisabetta;Saglietti, Laura;Schuchman, Edward H.;Furlan, Roberto;Clementi, Emilio;Matteoli, Michela;Verderio, Claudia
通讯作者：
Verderio, Claudia
影响因子：
2.5
作者：
Bain, MJ;Dwyer, SM;Rusak, B
通讯作者：
Rusak, B