Ototoxicity of Non-aminoglycoside Antibiotics.
Ototoxicity of Non-aminoglycoside Antibiotics.
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DOI：
10.3389/fneur.2021.652674
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发表时间：
2021
影响因子：
3.4
通讯作者：
Mukherjea D
中科院分区：
文献类型：
--
作者：
Rybak LP;Ramkumar V;Mukherjea D
众所周知，氨基糖苷类抗生素可以导致严重的听力损失和前庭功能障碍，这已经在动物研究和临床报告中得到了描述。本文对非氨基糖苷类抗生素耳毒性的相关临床前和临床文献进行综述。本报告讨论了在动物研究和患者中与听力损失有关的除氨基糖苷类以外的主要类别的抗生素。这些抗生素包括：卷曲霉素，一种多肽抗生素，已被用于治疗耐药结核病患者，特别是在发展中国家；大环内酯类药物，包括红霉素、阿奇霉素和克拉霉素；以及万古霉素。这些抗生素与耳毒性有关，特别是在新生儿中。意识到这些抗生素的耳毒性是至关重要的，因为文献中对氨基糖苷类抗生素的耳毒性给予了如此多的关注。
It is well-known that aminoglycoside antibiotics can cause significant hearing loss and vestibular deficits that have been described in animal studies and in clinical reports. The purpose of this review is to summarize relevant preclinical and clinical publications that discuss the ototoxicity of non-aminoglycoside antibiotics. The major classes of antibiotics other than aminoglycosides that have been associated with hearing loss in animal studies and in patients are discussed in this report. These antibiotics include: capreomycin, a polypeptide antibiotic that has been used to treat patients with drug-resistant tuberculosis, particularly in developing nations; the macrolides, including erythromycin, azithromycin and clarithromycin; and vancomycin. These antibiotics have been associated with ototoxicity, particularly in neonates. It is critical to be aware of the ototoxic potential of these antibiotics since so much attention has been given to the ototoxicity of aminoglycoside antibiotics in the literature.
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影响因子：
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作者：
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通讯作者：
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AGUSTI, C;FERRAN, F;PICADO, C
通讯作者：
PICADO, C