The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer.
The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer.
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DOI：
10.3390/ijms18081606
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发表时间：
2017-07-25
影响因子：
5.6
通讯作者：
Sakaida I
中科院分区：
文献类型：
--
作者：
Nishikawa J;Iizasa H;Yoshiyama H;Nakamura M;Saito M;Sasaki S;Shimokuri K;Yanagihara M;Sakai K;Suehiro Y;Yamasaki T;Sakaida I
爱泼斯坦-巴尔病毒(Epstein-Barr Virus，EBV)在全世界约10%的胃癌病例中检测到。在EBV相关性胃癌(EBVaGC)中，所有的肿瘤细胞都含有克隆的EBV基因组。潜伏的EBV基因的表达通过EBV DNA的甲基化受到严格的调控。病毒DNA的甲基化调节EBV潜伏期的类型，而肿瘤抑制基因的甲基化是EBVaGC的关键异常。EBVaGC中多个抑癌基因和细胞黏附分子的甲基化频率明显高于对照组。EBV来源的microRNAs抑制病毒和宿主mRNAs的翻译。EBV调控非编码RNA在胃癌中的表达。在去甲基化药物抗EBVaGC的临床应用方面，我们研究了地西他滨对EBVaGC细胞株的作用。地西他滨对EBVaGC细胞生长有抑制作用。P73和Run相关转录因子3(RUNX3)的启动子区域去甲基化，并上调其表达。我们综述了表观遗传调控在EBVaGC发生和维持中的作用，并讨论了DNA去甲基化药物在EBVaGC治疗中的应用。
The Epstein–Barr virus (EBV) is detected in about 10% of gastric carcinoma cases throughout the world. In EBV-associated gastric carcinoma (EBVaGC), all tumor cells harbor the clonal EBV genome. The expression of latent EBV genes is strictly regulated through the methylation of EBV DNA. The methylation of viral DNA regulates the type of EBV latency, and methylation of the tumor suppressor genes is a key abnormality in EBVaGC. The methylation frequencies of several tumor suppressor genes and cell adhesion molecules are significantly higher in EBVaGC than in control cases. EBV-derived microRNAs repress translation from viral and host mRNAs. EBV regulates the expression of non-coding RNA in gastric carcinoma. With regard to the clinical application of demethylating agents against EBVaGC, we investigated the effects of decitabine against the EBVaGC cell lines. Decitabine inhibited the cell growth of EBVaGC cells. The promoter regions of p73 and Runt-related transcription factor 3(RUNX3) were demethylated, and their expression was upregulated by the treatment. We review the role of epigenetic regulation in the development and maintenance of EBVaGC and discuss the therapeutic application of DNA demethylating agents for EBVaGC.
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在复发/难治性急性淋巴细胞性白血病中，有或没有超vad的5-aza-2'-脱氧胞苷（去替替啶）的安全性和临床活性。
影响因子：
6.5
作者：
Benton CB;Thomas DA;Yang H;Ravandi F;Rytting M;O'Brien S;Franklin AR;Borthakur G;Dara S;Kwari M;Pierce SR;Jabbour E;Kantarjian H;Garcia-Manero G
通讯作者：
Garcia-Manero G
DOI：
10.3390/v4123420
发表时间：
2012-12
期刊：
Viruses
影响因子：
--
作者：
Iizasa H;Nanbo A;Nishikawa J;Jinushi M;Yoshiyama H
通讯作者：
Yoshiyama H
影响因子：
--
作者：
Derks S;Liao X;Chiaravalli AM;Xu X;Camargo MC;Solcia E;Sessa F;Fleitas T;Freeman GJ;Rodig SJ;Rabkin CS;Bass AJ
通讯作者：
Bass AJ
影响因子：
5.4
作者：
Chen, HL;Huang, I;Hayward, SD
通讯作者：
Hayward, SD
影响因子：
3.8
作者：
ERNBERG, I;FALK, K;KLEIN, G
通讯作者：
KLEIN, G