Transcutaneous electrical nerve stimulation reduces pain, fatigue and hyperalgesia while restoring central inhibition in primary fibromyalgia.
Transcutaneous electrical nerve stimulation reduces pain, fatigue and hyperalgesia while restoring central inhibition in primary fibromyalgia.
复制标题
DOI：
10.1016/j.pain.2013.07.043
复制
发表时间：
2013-11
期刊：
影响因子：
7.4
通讯作者：
Sluka KA
中科院分区：
文献类型：
--
作者：
Dailey DL;Rakel BA;Vance CGT;Liebano RE;Amrit AS;Bush HM;Lee KS;Lee JE;Sluka KA
由于TENS通过降低中枢兴奋性和激活中枢抑制途径起作用，我们测试了TENS将减少疼痛和疲劳并改善纤维肌痛患者的功能和痛觉过敏的假设，这些患者具有增强的中枢兴奋性和减少的抑制。本研究采用双盲随机、安慰剂对照交叉设计，以测试纤维肌痛患者单次TENS治疗的效果。以随机顺序评估三种治疗：活性TENS、安慰剂TENS、无TENS。在每次TENS治疗之前和之后评估以下测量：休息和运动时的疼痛和疲劳、压力疼痛阈值（PPT）、6分钟步行试验（6MWT）、运动范围（ROM）、五次坐立试验（FTSTS）和单腿站立（SLS）。在测试结束时完成条件性疼痛调节（CPM）。与安慰剂和无TENS相比，活动TENS的疼痛和运动疲劳显著减少。与安慰剂TENS或无TENS相比，TENS部位（脊柱）和TENS外部部位（腿部）的PPT增加。在活动TENS期间，CPM与安慰剂TENS和无TENS相比显著更强。TENS没有观察到功能任务的变化。因此，目前的研究表明，TENS在缓解纤维肌痛症状方面具有短期疗效，而刺激剂是活跃的。未来的临床试验应该检查重复每日输送TENS的效果，类似于TENS在临床上的使用方式，对纤维肌痛患者的疼痛，疲劳，功能和生活质量的影响。
Because TENS works by reducing central excitability and activating central inhibition pathways, we tested the hypothesis that TENS would reduce pain and fatigue and improve function and hyperalgesia in people with fibromyalgia who have enhanced central excitability and reduced inhibition. The current study used a double-blinded randomized, placebo controlled cross-over design to test effects of a single treatment of TENS in people with fibromyalgia. Three treatments were assessed in random order: active TENS, placebo TENS, no TENS. The following measures were assessed before and after each TENS treatment: pain and fatigue at rest and movement, pressure pain thresholds (PPTs), 6 minute walk test (6MWT), range of motion (ROM), five time sit to stand test (FTSTS), and single leg stance (SLS). Conditioned pain modulation (CPM) was completed at end of testing. There was a significant decrease in pain and fatigue with movement for active TENS compared to placebo and no TENS. PPTs increased at site of TENS (spine) and outside site of TENS (leg) when compared to placebo TENS or no TENS. During Active TENS CPM was significantly stronger compared to placebo TENS and no TENS. No changes in functional tasks were observed with TENS. Thus, the current study suggests TENS has short-term efficacy in relieving symptoms of fibromyalgia while the stimulator is active. Future clinical trials should examine the effects of repeated daily delivery of TENS, similar to how TENS is used clinically, on pain, fatigue, function and quality of life in individuals with fibromyalgia.
登录
查看更多内容
影响因子：
4.9
作者：
Häuser W;Klose P;Langhorst J;Moradi B;Steinbach M;Schiltenwolf M;Busch A
通讯作者：
Busch A
影响因子：
3.7
作者：
Doig, GS;Simpson, F
通讯作者：
Simpson, F
影响因子：
--
作者：
Kop, WJ;Lyden, A;Clauw, DJ
通讯作者：
Clauw, DJ
影响因子：
0.6
作者：
Emmiler, Mustafa;Solak, Oezlem;Kavuncu, Vural
通讯作者：
Kavuncu, Vural
DOI：
10.1016/s0011-393x(05)80250-4
发表时间：
1993-02-01
影响因子：
1.9
作者：
DIBENEDETTO, P;IONA, LG;ZIDARICH, V
通讯作者：
ZIDARICH, V