Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss.
Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss.
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DOI：
10.3389/fncel.2017.00192
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发表时间：
2017
影响因子：
5.3
通讯作者：
Kalinec F
中科院分区：
文献类型：
--
作者：
Kalinec GM;Lomberk G;Urrutia RA;Kalinec F
大量研究支持炎症反应与药物、噪音和年龄相关的听力损失（DRHL、NRHL 和 ARHL）密切相关的观点。因此，目前正在密切关注一些旨在通过预防炎症来减少听觉功能障碍的临床策略。然而，炎症是一种正常的适应性反应，旨在在感染、组织损伤甚至无菌条件下的应激后恢复组织功能和稳态，抑制炎症可能会产生意想不到的负面后果。因此，预防或改善 DRHL、NRHL 和 ARHL 的适当方法应涉及改善耳蜗炎症过程的消退，而不是抑制这种现象。炎症的消退不是被动反应，而是一个主动、高度控制和协调的过程。炎症本身会产生具有关键功能的专门促消退介质，包括必需脂肪酸衍生物（脂氧素、消退素、保护素和 maresins）、蛋白质和肽（如膜联蛋白 A1 和半乳糖凝集素）、嘌呤（腺苷）、气体介质（NO、H2S 和 CO）以及神经调节剂（如乙酰胆碱和 netrin-1）。在这篇综述文章中，我们描述了对炎症消退阶段的理解的最新进展，并强调了可能有助于预防炎症引起的耳蜗损伤的治疗策略。我们特别强调已在顺铂和氨基糖苷类抗生素等公认的耳毒性药物诱导的炎症反应的临床前模型中进行测试的有益方法。由于这些研究表明改善解决过程可能有助于预防人类炎症相关疾病，因此我们讨论了类似策略预防或减轻 DRHL、NRHL 和 ARHL 的潜在应用。
A significant number of studies support the idea that inflammatory responses are intimately associated with drug-, noise- and age-related hearing loss (DRHL, NRHL and ARHL). Consequently, several clinical strategies aimed at reducing auditory dysfunction by preventing inflammation are currently under intense scrutiny. Inflammation, however, is a normal adaptive response aimed at restoring tissue functionality and homeostasis after infection, tissue injury and even stress under sterile conditions, and suppressing it could have unintended negative consequences. Therefore, an appropriate approach to prevent or ameliorate DRHL, NRHL and ARHL should involve improving the resolution of the inflammatory process in the cochlea rather than inhibiting this phenomenon. The resolution of inflammation is not a passive response but rather an active, highly controlled and coordinated process. Inflammation by itself produces specialized pro-resolving mediators with critical functions, including essential fatty acid derivatives (lipoxins, resolvins, protectins and maresins), proteins and peptides such as annexin A1 and galectins, purines (adenosine), gaseous mediators (NO, H2S and CO), as well as neuromodulators like acetylcholine and netrin-1. In this review article, we describe recent advances in the understanding of the resolution phase of inflammation and highlight therapeutic strategies that might be useful in preventing inflammation-induced cochlear damage. In particular, we emphasize beneficial approaches that have been tested in pre-clinical models of inflammatory responses induced by recognized ototoxic drugs such as cisplatin and aminoglycoside antibiotics. Since these studies suggest that improving the resolution process could be useful for the prevention of inflammation-associated diseases in humans, we discuss the potential application of similar strategies to prevent or mitigate DRHL, NRHL and ARHL.
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DOI：
10.4049/jimmunol.1003145
发表时间：
2011-04-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Brancaleone V;Dalli J;Bena S;Flower RJ;Cirino G;Perretti M
通讯作者：
Perretti M
影响因子：
20.3
作者：
Anong, William A.;Franco, Taina;Low, Philip S.
通讯作者：
Low, Philip S.
影响因子：
2.5
作者：
Bourien, Jerome;Tang, Yong;Wang, Jing
通讯作者：
Wang, Jing
影响因子：
11.8
作者：
Arur, S;Uche, UE;Han, DK
通讯作者：
Han, DK
影响因子：
5.3
作者：
Backhouse, Steven;Coleman, Bryony;Shepherd, Robert
通讯作者：
Shepherd, Robert