Prospects of nanotechnology in clinical immunodiagnostics.
Prospects of nanotechnology in clinical immunodiagnostics.
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DOI：
10.3390/s100706535
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Aldwayyan AS
中科院分区：
文献类型：
--
作者：
Ansari AA;Alhoshan M;Alsalhi MS;Aldwayyan AS
纳米结构材料是有前景的化合物，为检测生物分子的传感平台提供了新的机会。纳米材料具有微米级长度和纳米级直径，可以通过当前的纳米制造方法以及自组装技术来操纵，以制造纳米级生物传感设备。纳米结构材料具有非凡的物理、机械、电学、热学和多功能特性。这种独特的特性提倡将它们用作仿生膜来固定和修饰纳米颗粒表面的生物分子。排列、均匀分散、选择性生长和直径控制是一般参数，它们在成功集成纳米结构以制造生物电子传感器件中发挥着关键作用。在这篇综述中，我们重点关注纳米材料的不同类型和方面，包括它们的合成、性质、与生物分子的结合以及它们在免疫传感设备构建中的应用。通过关联每个传感器背后的概念和机制、实验条件以及传感器在不同条件下的行为等，总结了每篇引用文章的一些关键结果。各种基于纳米材料的生物电子器件表现出新颖的功能，证明了纳米材料在此类传感器件中的独特性能，未来必将继续扩大。这种基于纳米材料的设备预计将对临床免疫诊断、环境监测、安全监控和确保食品安全产生重大影响。
Nanostructured materials are promising compounds that offer new opportunities as sensing platforms for the detection of biomolecules. Having micrometer-scale length and nanometer-scale diameters, nanomaterials can be manipulated with current nanofabrication methods, as well as self-assembly techniques, to fabricate nanoscale bio-sensing devices. Nanostructured materials possess extraordinary physical, mechanical, electrical, thermal and multifunctional properties. Such unique properties advocate their use as biomimetic membranes to immobilize and modify biomolecules on the surface of nanoparticles. Alignment, uniform dispersion, selective growth and diameter control are general parameters which play critical roles in the successful integration of nanostructures for the fabrication of bioelectronic sensing devices. In this review, we focus on different types and aspects of nanomaterials, including their synthesis, properties, conjugation with biomolecules and their application in the construction of immunosensing devices. Some key results from each cited article are summarized by relating the concept and mechanism behind each sensor, experimental conditions and the behavior of the sensor under different conditions, etc. The variety of nanomaterial-based bioelectronic devices exhibiting novel functions proves the unique properties of nanomaterials in such sensing devices, which will surely continue to expand in the future. Such nanomaterial based devices are expected to have a major impact in clinical immunodiagnostics, environmental monitoring, security surveillance and for ensuring food safety.
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影响因子：
4.3
作者：
Chen, Jiwei;Jiang, Jianhui;Yu, Ruqin
通讯作者：
Yu, Ruqin
基于三维有序大孔金膜的电化学阻抗免疫传感器
影响因子：
7.4
作者：
Chen, Xiaojun;Wang, Yuanyuan;Zhu, Jun-Jie
通讯作者：
Zhu, Jun-Jie
影响因子：
5.4
作者：
Bhattacharya, A;Ganguly, KM;Sarkar, S
通讯作者：
Sarkar, S
DOI：
10.3390/s100100963
发表时间：
2010
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Abu-Salah KM;Alrokyan SA;Khan MN;Ansari AA
通讯作者：
Ansari AA
影响因子：
5
作者：
Ansari, Anees A.;Kaushik, Ajeet;Malhotra, B. D.
通讯作者：
Malhotra, B. D.