Pre-Conceptional Anti-Thyroid Antibodies and Thyroid Function in Association with Natural Conception Rates.
Pre-Conceptional Anti-Thyroid Antibodies and Thyroid Function in Association with Natural Conception Rates.
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DOI：
10.3390/ijerph192013177
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发表时间：
2022-10-13
影响因子：
--
通讯作者：
Mizuno, Yuki
中科院分区：
文献类型：
--
作者：
Konishi, Shoko;Mizuno, Yuki
甲状腺功能是内分泌系统的一个组成部分，支持受孕和怀孕。日本人经常食用海鲜和碘可能会对甲状腺功能产生不利影响。因此，在这项研究中，我们的目的是分析碘摄入量，甲状腺激素，自身免疫和自然受孕率之间的关系，在日本妇女试图怀孕他们的第一个孩子。一项为期24周的前瞻性研究针对80名没有不孕症史的妇女，她们不打算接受生育治疗。测量入组时血清中的尿碘浓度和甲状腺生物标志物浓度。35名妇女在随访期间自然受孕。尿碘浓度中位数（四分位数间距）为297（165，500）μg/L。游离三碘甲状腺原氨酸（T3）和游离甲状腺素（T4）与尿碘浓度呈负相关。校正年龄和性交频率后，与抗TPO <16 IU/mL的女性相比，抗TPO ≥ 16 IU/mL的女性受孕率较低（风险比：0.28，95%置信区间，0.08-0.92）。在调整年龄和性交频率后，抗甲状腺球蛋白抗体、游离T3、游离T4或促甲状腺激素与受孕率均无显著相关性。甲状腺自身免疫与自然受孕率之间的负相关性值得进一步研究。
Thyroid functioning is an integral part of the endocrine system that supports conception and pregnancy. Frequent consumption of seafood and iodine by Japanese people may adversely affect their thyroid function. Thus, in this study, we aimed to analyze the associations between iodine intake, thyroid hormones, autoimmunity, and natural conception rates in Japanese women trying to conceive their first child. A prospective study of 24 weeks targeted 80 women with no history of infertility, who did not plan to undergo fertility treatment. Concentrations of urinary iodine concentration and thyroid biomarkers in the serum at enrollment were measured. Thirty-five women naturally conceived during the follow-up. The median (inter-quartile range) urinary concentration of iodine was 297 (165, 500) μg/L. Free triiodothyronine (T3) and free thyroxin (T4) negatively correlated with urinary iodine concentrations. Women with anti-thyroid peroxidase (anti-TPO) ≥ 16 IU/mL had lower conception rates (hazard ratio: 0.28, 95% confidence interval, 0.08–0.92) compared with those with anti-TPO < 16 IU/mL, after adjusting for age and coital frequency. None of anti-thyroglobulin antibody, free T3, free T4, or thyroid-stimulating hormone showed significant associations with conception rate after adjusting for age and coital frequency. The negative association between thyroid autoimmunity and natural conception rates warrants further investigation.
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影响因子：
2.2
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.3390/ijerph18105486
发表时间：
2021-05-20
影响因子：
--
作者：
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通讯作者：
Ohtsuki H