Neuroimaging correlates of emotional response-inhibition discriminate between young depressed adults with and without sub-threshold bipolar symptoms (Emotional Response-inhibition in Young Depressed Adults).
Neuroimaging correlates of emotional response-inhibition discriminate between young depressed adults with and without sub-threshold bipolar symptoms (Emotional Response-inhibition in Young Depressed Adults).
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DOI：
10.1016/j.jad.2020.12.037
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发表时间：
2021-02-15
影响因子：
6.6
通讯作者：
Anand A
中科院分区：
文献类型：
--
作者：
Cha J;Speaker S;Hu B;Altinay M;Koirala P;Karne H;Spielberg J;Kuceyeski A;Dhamala E;Anand A
许多重度抑郁症（MDD）受试者表现出阈下躁狂症状（MDD+）。这项研究首次使用情绪抑制任务调查了MDD+受试者的神经组织是否更类似于双相抑郁症（BDD）或没有阈下双相症状的MDD受试者（MDD-）。本研究纳入了118名无药物治疗的年轻成人（15 - 30岁）：20例BDD、28例MDD+、41例MDD-和29例HC受试者。参与者在情绪和非情绪Go/No-go任务期间接受了fMRI，在此期间，他们对Go刺激做出反应，并对快乐，恐惧和非情绪（性别）面孔No-go刺激做出抑制反应。进行了组效应的单变量线性混合效应（LME）分析和多变量高斯过程分类器（GPC）分析。与BDD和MDD+组相比，MDD−组在情绪抑制条件下的顶叶、颞叶和额叶区域的激活显著低于非情绪条件下的激活（聚类校正p <0.05）。情感的GPC分类（快乐+恐惧）与非情绪反应抑制激活模式显示BDD和MDD-受试者之间有很好的区分（AUC：0.70;平衡准确度：70%（校正p = 0.018））以及MDD+和MDD-受试者之间（AUC：0.72;平衡准确度：67%（校正p = 0.045）），但BDD和MDD+组之间的区分效率较低（AUC：0.68;平衡准确度：61%（校正p = 0.273））。值得注意的是，MDD-组的分类是根据左杏仁核激活模式加权的。结果还需要在不同的独立数据集中进行测试。使用fMRI情绪Go-Nogo任务，MDD−受试者可以与BDD和MDD+受试者区分开来。
Many subjects with major depression (MDD) exhibit subthreshold mania symptoms (MDD+). This study investigated, for the first time, using emotional inhibition tasks, whether the neural organization of MDD+ subjects is more similar to bipolar depression (BDD) or to MDD subjects without subthreshold bipolar symptoms (MDD−). This study included 118 medication-free young adults (15 – 30 yrs.): 20 BDD, 28 MDD+, 41 MDD− and 29 HC subjects. Participants underwent fMRI during emotional and non-emotional Go/No-go tasks during which they responded for Go stimuli and inhibited response for happy, fear, and non-emotional (gender) faces No-go stimuli. Univariate linear mixed-effects (LME) analysis for group effects and multivariate Gaussian Process Classifier (GPC) analyses were conducted. MDD− group compared to both the BDD and MDD+ groups, exhibited significantly lower activation in parietal, temporal and frontal regions (cluster-wise corrected p <0.05) for emotional inhibition conditions vs. non-emotional condition. GPC classification of emotional (happy + fear) vs. non-emotional response-inhibition activation pattern showed good discrimination between BDD and MDD− subjects (AUC: 0.70; balanced accuracy: 70% (corrected p = 0.018)) as well as between MDD+ and MDD− subjects (AUC: 0.72; balanced accuracy: 67% (corrected p = 0.045)) but less efficient discrimination between BDD and MDD+ groups (AUC: 0.68; balanced accuracy: 61% (corrected p = 0.273)). Notably, classification of the MDD− group was weighted for left amygdala activation pattern. Results also need to be tested in a different independent dataset. Using an fMRI emotional Go-Nogo task, MDD− subjects can be discriminated from BDD and MDD+ subjects.
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影响因子：
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作者：
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通讯作者：
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