Dendritic cell migration in inflammation and immunity.
Dendritic cell migration in inflammation and immunity.
复制标题
炎症和免疫中的树突状细胞迁移
DOI：
10.1038/s41423-021-00726-4
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发表时间：
2021-11
影响因子：
24.1
通讯作者：
Cao X
中科院分区：
文献类型：
--
作者：
Liu J;Zhang X;Cheng Y;Cao X
树突状细胞（Dendritic cells，DCs）是连接天然免疫和获得性免疫的关键环节，在促进免疫防御和维持免疫耐受中发挥重要作用。不同DC亚群在淋巴和非淋巴组织中的运输对于DC依赖性激活和调节炎症和免疫是必不可少的。DC的趋化和迁移是由趋化因子及其受体之间的相互作用触发的，并以组织特异性方式受到多种细胞内机制的调节，如蛋白质修饰、表观遗传重编程、代谢重塑和细胞骨架重排。DC迁移的失调可能导致DC的异常定位或激活，从而导致免疫应答的失衡，甚至免疫病理，包括自身免疫应答、感染性疾病、过敏性疾病和肿瘤。针对不同DC亚群迁移的新策略正在探索用于治疗炎症和感染性疾病以及开发新型DC疫苗。在这篇综述中，我们将讨论不同的DC亚群的迁移途径和免疫学后果，DC中迁移信号的分子基础和调节机制，以及DC迁移与自身免疫性疾病和感染性疾病的发病机制的关联。
Dendritic cells (DCs) are the key link between innate immunity and adaptive immunity and play crucial roles in both the promotion of immune defense and the maintenance of immune tolerance. The trafficking of distinct DC subsets across lymphoid and nonlymphoid tissues is essential for DC-dependent activation and regulation of inflammation and immunity. DC chemotaxis and migration are triggered by interactions between chemokines and their receptors and regulated by multiple intracellular mechanisms, such as protein modification, epigenetic reprogramming, metabolic remodeling, and cytoskeletal rearrangement, in a tissue-specific manner. Dysregulation of DC migration may lead to abnormal positioning or activation of DCs, resulting in an imbalance of immune responses and even immune pathologies, including autoimmune responses, infectious diseases, allergic diseases and tumors. New strategies targeting the migration of distinct DC subsets are being explored for the treatment of inflammatory and infectious diseases and the development of novel DC-based vaccines. In this review, we will discuss the migratory routes and immunological consequences of distinct DC subsets, the molecular basis and regulatory mechanisms of migratory signaling in DCs, and the association of DC migration with the pathogenesis of autoimmune and infectious diseases.
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DOI：
10.1084/jem.20051035
发表时间：
2005-09-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Diacovo TG;Blasius AL;Mak TW;Cella M;Colonna M
通讯作者：
Colonna M
DOI：
10.4049/jimmunol.1102613
发表时间：
2012-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
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通讯作者：
Kovats S
影响因子：
30.5
作者：
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通讯作者：
Heath, William R.
影响因子：
32.4
作者：
Baratin, Myriam;Foray, Chloe;Lawrence, Toby
通讯作者：
Lawrence, Toby
影响因子：
64.5
作者：
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通讯作者：
Pan F