Blood oxygen level-dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys.
Blood oxygen level-dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys.
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DOI：
10.1016/j.mri.2009.05.044
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发表时间：
2010-01
影响因子：
2.5
通讯作者：
Fain, Sean B.
中科院分区：
文献类型：
--
作者：
Sadowski, Elizabeth A.;Djamali, Arjang;Wentland, Andrew L.;Muehrer, Rebecca;Becker, Bryan N.;Grist, Thomas M.;Fain, Sean B.
功能磁共振成像 (fMRI) 是检查肾功能的强大工具，包括器官血流量和氧气生物利用度。我们使用对比增强灌注和血氧水平依赖 (BOLD) MR 成像来评估肾移植的功能正常、急性肾小管坏死 (ATN) 和急性排斥反应。对 17 名最近移植肾脏的受试者进行了 BOLD 和 MR 灌注成像。与ATN同种异体移植物（R2*=19.8/s；P=0.047）和功能正常同种异体移植物（R2*=24.3/s；P=0.0003）相比，急性排斥组的髓质R2*值（R2*=16.2/s）有显着差异。急性排斥组髓质灌注测量（124.4±41.1 ml/100g/min）与ATN组（246.9±123.5 ml/100g/min；P=0.02）和功能正常同种异体移植组（220.8±95.8 ml/100g/min；P=0.02）相比，差异有统计学意义。这项研究强调了结合灌注和 BOLD MR 成像来评估肾功能的效用。我们已经证明，在那些患有急性排斥反应的同种异体移植物中，BOLD MR 成像显示髓质 R2*（脱氧血红蛋白减少）减少，并且 MR 灌注成像显示髓质血流量减少，这表明尽管血流量减少，但发生排斥反应的同种异体移植物中髓质氧生物利用度增加。
Functional magnetic resonance imaging (fMRI) is a powerful tool for examining kidney function, including organ blood flow and oxygen bioavailability. We have used contrast enhanced perfusion and blood oxygen level dependent (BOLD) MR imaging to assess kidney transplants with normal function, acute tubular necrosis (ATN) and acute rejection. BOLD and MR-perfusion imaging were performed on seventeen subjects with recently transplanted kidneys. There was a significant difference between medullary R2* values in the group with acute rejection (R2*=16.2/s) compared to allografts with ATN (R2*=19.8/s;P=0.047) and normal-functioning allografts (R2*=24.3/s;P=0.0003). There was a significant difference between medullary perfusion measurements in the group with acute rejection (124.4±41.1 ml/100g/min) compared to those in patients with ATN (246.9±123.5 ml/100g/min;P=0.02) and normal-functioning allografts (220.8±95.8 ml/100g/min;P=0.02). This study highlights the utility of combining perfusion and BOLD MR imaging to assess renal function. We have demonstrated a decrease in medullary R2* (decrease deoxyhemoglobin) on BOLD MR imaging and a decrease in medullary blood flow by MR perfusion imaging in those allografts with acute rejection, which indicates an increase in medullary oxygen bioavailability in allografts with rejection, despite a decrease in blood flow.
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影响因子：
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作者：
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发表时间：
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影响因子：
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