Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cognitive behavior despite widespread brain pathology.
Acquired infection with Toxoplasma gondii in adult mice results in sensorimotor deficits but normal cognitive behavior despite widespread brain pathology.
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DOI：
10.1016/j.micinf.2010.03.009
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发表时间：
2010-07
影响因子：
5.8
通讯作者：
Weiss LM
中科院分区：
文献类型：
--
作者：
Gulinello M;Acquarone M;Kim JH;Spray DC;Barbosa HS;Sellers R;Tanowitz HB;Weiss LM
弓形虫是一种普遍存在的细胞内寄生虫，慢性感染人类人口的30%至50%。虽然获得性感染主要是无症状的，但几项研究表明，这种感染可能会导致神经和精神症状。以前对啮齿动物的研究表明，弓形虫感染不仅会杀死宿主，还会改变受感染动物的行为模式，使其更有可能完成寄生虫的生命周期。本研究的目的是在综合测试组中评价慢性感染无毒弓形虫(ME49，II型株)的C57BL/6小鼠的行为变化。感染的小鼠表现出深刻而广泛的脑部病理，运动协调和感觉障碍。相比之下，认知功能、焦虑水平、社交行为和探索新对象的动机都是正常的。观察到的行为变化并不代表大脑的“严重”损伤或功能障碍，也不是由于大脑特定区域的有针对性的破坏。这些变化指出了这种寄生虫与其中间宿主的微妙相互作用，并与捕食增加是感染的结果的观点一致。
Toxoplasma gondii is a ubiquitous intracellular parasite which chronically infects 30 to 50% of the human population. While acquired infection is primarily asymptomatic several studies have suggested that such infections may contribute to neurological and psychiatric symptoms. Previous studies in rodents have demonstated that T. gondii infection does not just kill its host, but alters the behavioral repertoire of an infected animal making it more likely that predation with occur completing the parasite life cycle. The aim of the present study was to evaluate the behavioral changes in C57BL/6 mice chronically infected with the avirulent T. gondii (ME49, a type II strain), in a comprehensive test battery. Infected mice demonstrated profound and widespread brain pathology, motor coordination and sensory deficits. In contrast, cognitive function, anxiety levels, social behavior and the motivation to explore novel objects were normal. The observed changes in behavior did not represent “gross” brain damage or dysfunction and were not due to targeted destruction of specific areas of the brain. Such changes point out the subtle interaction of this parasite with its intermediate hosts and are consistent with ideas about increased predation being an outcome of infection.
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DOI：
10.1080/00034983.1990.11812448
发表时间：
1990-04-01
影响因子：
--
作者：
ARNOTT, MA;CASSELLA, JP;HAY, J
通讯作者：
HAY, J
影响因子：
2.7
作者：
Gonzalez, Luis E.;Rojnik, Belen;Hernandez, Luis
通讯作者：
Hernandez, Luis
影响因子：
2.6
作者：
Dubey, JP
通讯作者：
Dubey, JP
影响因子：
6.6
作者：
Carruthers, Vern B.;Suzuki, Yasuhiro
通讯作者：
Suzuki, Yasuhiro
影响因子：
9.4
作者：
Howe, DK;Honore, S;Sibley, LD
通讯作者：
Sibley, LD