Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.
Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.
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DOI：
10.1371/journal.pone.0079848
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Delcourt C
中科院分区：
文献类型：
--
作者：
Merle BM;Maubaret C;Korobelnik JF;Delyfer MN;Rougier MB;Lambert JC;Amouyel P;Malet F;Le Goff M;Dartigues JF;Barberger-Gateau P;Delcourt C
据报道，涉及高密度脂蛋白（HDL）代谢的几个基因与年龄相关性黄斑变性（AMD）有关。此外，HDL转运两种类胡萝卜素，叶黄素和玉米黄质，这被高度怀疑在预防AMD中发挥关键作用。目的是确认HDL相关位点与AMD的关联，并评估其与血浆叶黄素和玉米黄质浓度的关联。Alienor研究是一项前瞻性人群研究，在法国波尔多的963名老年居民中进行营养和年龄相关眼病研究。根据非散瞳彩色视网膜照片，根据国际分类对AMD进行分级。血浆叶黄素和玉米黄质测定正相高效液相色谱法。研究了以下多态性：rs 493258和rs 10468017（LIPC），rs3764261（CETP），rs 12678919（LPL）和rs 1883025（ABCA 1）。多变量校正后，LIPC rs 493258变异体的TT基因型与早期和晚期AMD的风险降低显著相关。（OR=0.64，95%CI：0.41-0.99; p=0.049和OR=0.26，95%CI：0.08-0.85; p=0.03），并且具有较高的血浆玉米黄质浓度（p=0.03），而血浆脂质根据该SNP没有显著差异。此外，LPL变异与早期AMD相关（OR=0.67，95%CI：0.45-1.00; p=0.05），与血脂和血浆叶黄素相关（p=0.047）。LIPC rs 10468017、CETP和ABCA 1基因多态性与AMD的相关性未达到统计学显著性。这些发现表明LIPC和LPL基因都可以改变AMD的风险以及叶黄素和玉米黄质的代谢。
Several genes implicated in high-density lipoprotein (HDL) metabolism have been reported to be associated with age-related macular degeneration (AMD). Furthermore, HDL transport the two carotenoids, lutein and zeaxanthin, which are highly suspected to play a key-role in the protection against AMD. The objective is to confirm the associations of HDL-related loci with AMD and to assess their associations with plasma lutein and zeaxanthin concentrations. Alienor study is a prospective population-based study on nutrition and age-related eye diseases performed in 963 elderly residents of Bordeaux, France. AMD was graded according to the international classification, from non-mydriatic colour retinal photographs. Plasma lutein and zeaxanthin were determined by normal-phase high-performance liquid chromatography. The following polymorphisms were studied: rs493258 and rs10468017 (LIPC), rs3764261 (CETP), rs12678919 (LPL) and rs1883025 (ABCA1). After multivariate adjustment, the TT genotype of the LIPC rs493258 variant was significantly associated with a reduced risk for early and late AMD (OR=0.64, 95%CI: 0.41-0.99; p=0.049 and OR=0.26, 95%CI: 0.08-0.85; p=0.03, respectively), and with higher plasma zeaxanthin concentrations (p=0.03), while plasma lipids were not significantly different according to this SNP. Besides, the LPL variant was associated with early AMD (OR=0.67, 95%CI: 0.45-1.00; p=0.05) and both with plasma lipids and plasma lutein (p=0.047). Associations of LIPC rs10468017, CETP and ABCA1 polymorphisms with AMD did not reach statistical significance. These findings suggest that LIPC and LPL genes could both modify the risk for AMD and the metabolism of lutein and zeaxanthin.
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影响因子：
13.7
作者：
Klein, R;Klein, BEK;Jacobs, DR
通讯作者：
Jacobs, DR
影响因子：
4.4
作者：
Delcourt, Cecile;Delyfer, Marie-Noelle;Korobelnik, Jean-Francois
通讯作者：
Korobelnik, Jean-Francois
影响因子：
3.5
作者：
Cipriani, Valentina;Leung, Hin-Tak;Yates, John R. W.
通讯作者：
Yates, John R. W.
影响因子：
2.1
作者：
Li, Yun;Willer, Cristen J.;Ding, Jun;Scheet, Paul;Abecasis, Goncalo R.
通讯作者：
Abecasis, Goncalo R.
影响因子：
30.8
作者：
Kathiresan S;Willer CJ;Peloso GM;Demissie S;Musunuru K;Schadt EE;Kaplan L;Bennett D;Li Y;Tanaka T;Voight BF;Bonnycastle LL;Jackson AU;Crawford G;Surti A;Guiducci C;Burtt NP;Parish S;Clarke R;Zelenika D;Kubalanza KA;Morken MA;Scott LJ;Stringham HM;Galan P;Swift AJ;Kuusisto J;Bergman RN;Sundvall J;Laakso M;Ferrucci L;Scheet P;Sanna S;Uda M;Yang Q;Lunetta KL;Dupuis J;de Bakker PI;O'Donnell CJ;Chambers JC;Kooner JS;Hercberg S;Meneton P;Lakatta EG;Scuteri A;Schlessinger D;Tuomilehto J;Collins FS;Groop L;Altshuler D;Collins R;Lathrop GM;Melander O;Salomaa V;Peltonen L;Orho-Melander M;Ordovas JM;Boehnke M;Abecasis GR;Mohlke KL;Cupples LA
通讯作者：
Cupples LA