Pulmonary function and health-related quality of life after COVID-19 pneumonia.
Pulmonary function and health-related quality of life after COVID-19 pneumonia.
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DOI：
10.1016/j.rmed.2020.106272
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发表时间：
2021-01
影响因子：
4.3
通讯作者：
De Backer IC
中科院分区：
文献类型：
--
作者：
van der Sar-van der Brugge S;Talman S;Boonman-de Winter L;de Mol M;Hoefman E;van Etten RW;De Backer IC
背景资料。新冠肺炎大流行导致了许多肺炎病例，CT扫描显示出广泛的肺部异常。新冠肺炎肺炎对幸存者肺功能和生活质量的影响尚不得而知。本研究旨在探讨新冠肺炎肺炎对患者肺功能、健康相关生活质量及呼吸困难的影响。方法：研究方法。对聚合酶链式反应证实的非危重新冠肺炎肺炎后出院的患者进行前瞻性纵向队列研究。根据世卫组织的定义，病例被归类为中度或重度肺炎。出院6周后，受试者接受访谈和肺功能测试，并完成问卷，以评估他们的HRQOL、呼吸困难(BorgScale和MMRC)以及抑郁和焦虑症状(HADS)。结果。共纳入101例患者。新冠肺炎肺炎中度肺炎28例(27.7%)，重度肺炎73例(72.3%)。弥散受限(DLCOc和Lt；预测值的80%)在92例中66例(71.7%)，梗阻26例(25.7%)，限制21例(21.2%)。重症肺炎后患者的扩散能力明显降低。在整个组中，抑郁的HADS得分≥8占16.6%，焦虑的HADS得分12.5%。在SF-36的所有领域中，除了身体疼痛，都发现了显著的损害。FEV1和DLCOc与MMRC评分和SF-36多个领域呈显著正相关，尤其与躯体功能呈显著正相关。结论。新冠肺炎非危重肺炎存活者出院6周后弥散能力和生活质量明显受损。
Background. The COVID-19 pandemic has led to many cases of pneumonia with extensive lung abnormalities on CT-scans. The consequences of COVID-19 pneumonia on survivors’ pulmonary function and quality of life are unknown. The purpose of this study is to examine the impact of COVID-19 pneumonia on pulmonary function, health-related quality of life (HRQoL) and perceived dyspnoea. Methods. A prospective longitudinal cohort study regarding patients discharged from our hospital after PCR-proven, non-critical COVID-19 pneumonia was conducted. Cases were classified as moderate or severe pneumonia according to WHO definitions. Six weeks post-discharge subjects underwent interviews and pulmonary function tests, and completed questionnaires to assess their HRQoL, perceived dyspnoea (Borgscale and mMRC), and symptoms of depression and anxiety (HADS). Results. 101 patients were included. Twenty-eight (27.7%) pneumonias were classified as moderate cases of COVID-19 pneumonia and 73 (72.3%) were classified as severe cases. Diffusion limitation (DLCOc < 80% of predicted value) was found in 66 (71.7%) of 92 cases, obstruction in 26 (25.7%) of 101, and restriction in 21 (21.2%) of 99. Diffusion capacity was significantly lower in cases after severe pneumonia. In the entire group, HADS scores ≥8 for depression were found in 16.6% and in 12.5% for anxiety. Across all SF-36 domains, except for bodily pain, significant impairment was found. FEV1 and DLCOc showed significant positive correlations with mMRC scores and multiple SF-36 domains, especially physical functioning. Conclusion. COVID-19 non-critical pneumonia survivors have significant impairment in diffusion capacity and HRQOL six weeks after being discharged from hospital.
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影响因子：
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作者：
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影响因子：
7.2
作者：
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Verrips, E