Biomarkers of gastric cancer: Current topics and future perspective.

Biomarkers of gastric cancer: Current topics and future perspective.
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DOI:
10.3748/wjg.v24.i26.2818
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发表时间:
2018-07-14
影响因子:
4.3
通讯作者:
Yashiro M
Yashiro M
中科院分区:
医学2区
文献类型:
--
作者:
Matsuoka T;Yashiro M

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胃癌是世界上最常见的恶性肿瘤之一,是一种侵袭性疾病,5年生存率低。这种癌症在生物学和遗传学上是异质性的,在分子水平上对致癌作用知之甚少。虽然胃癌的发病率在下降,但胃癌患者的预后仍然很差。因此,在早期阶段利用有用的筛查方法,选择适当的治疗计划,有效的监测是关键,以减少GC死亡率。在临床信息和综合基因组分析的基础上鉴定生物标志物可以改善诊断、预后、复发预测和治疗反应。本文综述了胃癌生物标志物的研究现状和方法,并对胃癌的分子分类和特征分析进行了展望。
Gastric cancer (GC) is one of the most prevalent malignant types in the world and an aggressive disease with a poor 5-year survival. This cancer is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Although the incidence is declining, the outcome of patients with GC remains dismal. Thus, the detection at an early stage utilizing useful screening approaches, selection of an appropriate treatment plan, and effective monitoring is pivotal to reduce GC mortalities. Identification of biomarkers in a basis of clinical information and comprehensive genome analysis could improve diagnosis, prognosis, prediction of recurrence and treatment response. This review summarized the current status and approaches in GC biomarker, which could be potentially used for early diagnosis, accurate prediction of therapeutic approaches and discussed the future perspective based on the molecular classification and profiling.
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