Maternal occupational exposure to polycyclic aromatic hydrocarbons and the risk of isolated congenital heart defects among offspring.
Maternal occupational exposure to polycyclic aromatic hydrocarbons and the risk of isolated congenital heart defects among offspring.
复制标题
DOI：
10.1016/j.envres.2020.109550
复制
发表时间：
2020-07
影响因子：
8.3
通讯作者：
National Birth Defects Prevention Study
中科院分区：
文献类型：
--
作者：
Patel J;Nembhard WN;Politis MD;Rocheleau CM;Langlois PH;Shaw GM;Romitti PA;Gilboa SM;Desrosiers TA;Insaf T;Lupo PJ;National Birth Defects Prevention Study
虽然在实验模型系统中有证据表明，暴露于多环芳烃（PAH）与先天性心脏病（CHD）有关，但很少有研究在人类中研究这种关联。我们使用国家出生缺陷预防研究（NBDPS）（1997-2011）的数据进行了一项病例对照研究，以检查母体暴露于多环芳烃与后代CHD之间的关联。我们获得了详细的资料，母亲的职业在怀孕前一个月至三个月后。专家评分员对病例对照状态不知情，评估工作描述以分配暴露的分类水平。类别进行了定量映射，估计累积暴露于多环芳烃，包括暴露强度，频率，工作时间和工作时间。四分位数产生的累积母体暴露于多环芳烃。使用PAH暴露量四分位数和6个CHD分组（例如圆锥动脉干）和特定亚型（例如法洛四联症[ToF]）的非条件logistic回归估计粗比值比（OR）和校正比值比（OR）及其95%置信区间（CI）。根据母亲年龄、人种/种族、教育、吸烟、抗惊厥药使用、叶酸补充和研究中心调整最终模型。有4，775例病例和7，734例对照婴儿符合研究条件。职业暴露于多环芳烃的患病率为10.2%的病例和对照组的母亲。在校正分析中，与没有职业性PAH暴露的母亲相比，暴露量最高四分位数的母亲更有可能在圆锥动脉干心脏缺陷组（OR 1.41; 95% CI 1.00-2.00）和ToF组（OR 1.83; 95% CI 1.21-2.78）中生育后代。与没有职业性PAH暴露的女性相比，在妊娠早期估计累积职业性PAH暴露的最高四分位数的女性更有可能有圆锥动脉干心脏缺陷的后代，特别是ToF。多环芳烃和其他冠心病亚组之间的其他比较没有显示任何统计学上精确的关联。
Although there is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) is linked with congenital heart defects (CHDs), few studies have examined the association in humans. We conducted a case-control study to examine the association between maternal exposure to PAHs and CHDs in offspring using data from the National Birth Defects Prevention Study (NBDPS) (1997–2011). We obtained detailed information on maternal occupation during the month before to three months after conception. Expert raters, masked to case-control status, assessed job descriptions to assign categorical levels of exposure. Categories were quantitatively mapped to estimate cumulative exposure to PAHs, incorporating exposure intensity, frequency, work duration, and work hours. Quartiles were generated for cumulative maternal exposure to PAHs. Crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using unconditional logistic regression for quartiles of PAH exposure and six CHD groupings (e.g. conotruncal) and specific subtypes (e.g. tetralogy of Fallot [ToF]). Final models were adjusted for maternal age, race/ethnicity, education, smoking, anticonvulsant use, folic acid supplementation, and study center. There were 4,775 case and 7,734 control infants eligible for the study. The prevalence of occupational exposure to PAHs was 10.2% among both case and control mothers. In adjusted analysis, compared to mothers with no occupational PAH exposure, those in the highest quartile of exposure were more likely to have offspring in the conotruncal heart defects group (OR 1.41; 95% CI 1.00–2.00), and with ToF (OR 1.83; 95% CI 1.21–2.78). Women in the highest quartile of estimated cumulative occupational PAH exposure during early pregnancy were more likely to have offspring with conotruncal heart defects, specifically ToF, compared to women with no occupational PAH exposure. Other comparisons between PAHs and other CHDs subgroups did not show any statistically precise associations.
登录
查看更多内容
在国家出生缺陷的预防研究中，母体职业暴露于多环芳族烃和先天性心脏缺陷。
DOI：
10.1002/bdra.23071
发表时间：
2012-11
期刊：
Birth defects research. Part A, Clinical and molecular teratology
影响因子：
--
作者：
Lupo PJ;Symanski E;Langlois PH;Lawson CC;Malik S;Gilboa SM;Lee LJ;Agopian AJ;Desrosiers TA;Waters MA;Romitti PA;Correa A;Shaw GM;Mitchell LE;National Birth Defects Prevention Study
通讯作者：
National Birth Defects Prevention Study
影响因子：
5
作者：
Gilboa, SM;Mendola, P;Fixler, DE
通讯作者：
Fixler, DE
影响因子：
9.8
作者：
Gilboa, Suzanne M.;Correa, Adolfo;Riehle-Colarusso, Tiffany J.
通讯作者：
Riehle-Colarusso, Tiffany J.
DOI：
10.1016/j.mrgentox.2009.12.018
发表时间：
2010-02-02
影响因子：
1.9
作者：
Hanzalova, Katerina;Rossner, Pavel, Jr.;Sram, Radim J.
通讯作者：
Sram, Radim J.
DOI：
10.1038/jes.2009.19
发表时间：
2010-06-01
影响因子：
4.5
作者：
Naufal, Ziad;Li Zhiwen;Donnelly, Kirby C.
通讯作者：
Donnelly, Kirby C.