Three-Dimensional Augmented Reality Visualization Informs Locoregional Therapy in a Translational Model of Hepatocellular Carcinoma.
Three-Dimensional Augmented Reality Visualization Informs Locoregional Therapy in a Translational Model of Hepatocellular Carcinoma.
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DOI：
10.1016/j.jvir.2020.01.028
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Gade TP
中科院分区：
文献类型：
--
作者：
Park BJ;Perkons NR;Profka E;Johnson O;Morley C;Appel S;Nadolski GJ;Hunt SJ;Gade TP
目的探讨增强现实(AR)技术在肝细胞癌(HCC)肝动脉栓塞术(TAE)前的三维可视化应用价值。一项前瞻性研究包括28只大鼠，包括二乙基亚硝胺(DEN)诱导的肝癌和TAE治疗的大于5 mm的肿瘤。在12只大鼠中，在TAE前对术前MRI进行3D AR可视化。将包括导尿时间和辐射暴露在内的操作指标与16只大鼠的前瞻性队列进行了比较，其中16只大鼠在没有AR的情况下进行了TAE。另外确定了15个回顾病例的队列，并与前瞻性对照队列(n=31)相结合，以提高统计能力。前瞻性比较，AR术后透视时间从11.7分钟减少到7.4分钟(37%；P=0.12)，但与前瞻性对照和回顾性对照相比，透视时间从14.1分钟减少到7.4分钟(48%；P=0.01)，差异无统计学意义。前瞻性比较，AR术后总导尿时间由42.7分钟缩短至31.0分钟(27%；P=0.11)，但无统计学意义。剂量面积乘积(DAP)和空气比释动能(AK)前瞻性差异无统计学意义。术前成像的3D AR可视化可能有助于减少临床前TACE模型中的操作指标。这些数据支持进一步研究的必要性，以评估AR在血管内肿瘤干预中的潜力。
To evaluate the utility of visualizing pre-procedure MRI in three-dimensional (3D) space using augmented reality (AR) prior to transarterial embolization (TAE) of hepatocellular carcinoma (HCC) in a preclinical model. A prospective study with a total of 28 rats with diethylnitrosamine (DEN)-induced HCC and tumors greater than 5 mm treated with TAE were included. In 12 rats, 3D AR visualization of the pre-procedure MRI was performed prior to TAE. Procedural metrics including catheterization time and radiation exposure were compared to a prospective cohort of 16 rats in whom TAE was performed without AR. An additional cohort of 15 retrospective cases were identified and combined with the prospective control cohort (n=31) to improve statistical power. A reduction in fluoroscopy time was observed after AR when compared prospectively from 11.7 to 7.4 min (37%; p=0.12), which did not reach statistical significance; however, when compared to combined prospective and retrospective controls, the reduction in fluoroscopy time was significant from 14.1 to 7.4 min (48%; p=0.01). A reduction in total catheterization time was also observed after AR when compared prospectively from 42.7 to 31.0 min (27%; p=0.11), which did not reach statistical significance. No significant differences were seen in dose area product (DAP) or air kerma (AK) prospectively. 3D AR visualization of pre-procedural imaging may aid in the reduction of procedural metrics in a preclinical model of TACE. These data support the need for further studies to evaluate the potential of AR on endovascular oncologic interventions.
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DOI：
10.1016/j.jvir.2017.03.037
发表时间：
2017-07
期刊：
Journal of vascular and interventional radiology : JVIR
影响因子：
--
作者：
Kiefer RM;Hunt SJ;Pulido S;Pickup S;Furth EE;Soulen MC;Nadolski GJ;Gade TP
通讯作者：
Gade TP
DOI：
10.1016/j.jvir.2018.02.018
发表时间：
2018-07-01
影响因子：
2.9
作者：
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通讯作者：
Kothary, Nishita
影响因子：
5.5
作者：
Mitsouras, Dimitris;Liacouras, Peter;Rybicki, Frank J.
通讯作者：
Rybicki, Frank J.
影响因子：
3.9
作者：
Tack P;Victor J;Gemmel P;Annemans L
通讯作者：
Annemans L
影响因子：
2
作者：
Karmonik, Christof;Elias, Saba N.;Britz, Gavin W.
通讯作者：
Britz, Gavin W.