Seroprevalence of antibodies against Chikungunya, Dengue, and Rift Valley fever viruses after febrile illness outbreak, Madagascar.
Seroprevalence of antibodies against Chikungunya, Dengue, and Rift Valley fever viruses after febrile illness outbreak, Madagascar.
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DOI：
10.3201/eid1811.111036
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发表时间：
2012-11
影响因子：
11.8
通讯作者：
Rakotozandrindrainy R
中科院分区：
文献类型：
--
作者：
Schwarz NG;Girmann M;Randriamampionona N;Bialonski A;Maus D;Krefis AC;Njarasoa C;Rajanalison JF;Ramandrisoa HD;Randriarison ML;May J;Schmidt-Chanasit J;Rakotozandrindrainy R
2009年10月，在马达加斯加东海岸爆发伴有关节疼痛的发热性疾病后2 -3个月，我们评估了6个地点1，244名孕妇的基孔肯雅病毒（CHIKV）、登革热病毒（DENV）和裂谷热病毒（RVFV）的血清学标志物。在两个东部沿海城镇，抗CHIKV的IgG血清阳性率为45%和23%; IgM血清阳性率为28%和5%。登革病毒IgG阳性率分别为17%和11%。未检测到抗DENV IgM。在450- 1，300 m高的4个地点，针对CHIKV的IgG血清阳性率为0%-3%，表明CHIKV尚未传播到更高的内陆海拔。四名妇女有抗RVFV的IgG，可能是2008年流行病的抗体。来自沿海地区的大多数（78%）患有CHIKV特异性IgG的妇女报告关节疼痛和僵硬; 21%报告没有症状。CHIKV感染与高体重显著相关。该暴发是一次孤立的CHIKV流行，没有相关的DENV共传播。
In October 2009, two–3 months after an outbreak of a febrile disease with joint pain on the eastern coast of Madagascar, we assessed serologic markers for chikungunya virus (CHIKV), dengue virus (DENV), and Rift Valley fever virus (RVFV) in 1,244 pregnant women at 6 locations. In 2 eastern coast towns, IgG seroprevalence against CHIKV was 45% and 23%; IgM seroprevalence was 28% and 5%. IgG seroprevalence against DENV was 17% and 11%. No anti-DENV IgM was detected. At 4 locations, 450–1,300 m high, IgG seroprevalence against CHIKV was 0%–3%, suggesting CHIKV had not spread to higher inland-altitudes. Four women had IgG against RVFV, probably antibodies from a 2008 epidemic. Most (78%) women from coastal locations with CHIKV-specific IgG reported joint pain and stiffness; 21% reported no symptoms. CHIKV infection was significantly associated with high bodyweight. The outbreak was an isolated CHIKV epidemic without relevant DENV co-transmission.
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影响因子：
11.8
作者：
Leroy EM;Nkoghe D;Ollomo B;Nze-Nkogue C;Becquart P;Grard G;Pourrut X;Charrel R;Moureau G;Ndjoyi-Mbiguino A;De-Lamballerie X
通讯作者：
De-Lamballerie X
影响因子：
4.2
作者：
Staikowsky, F.;Le Roux, K.;Michault, A.
通讯作者：
Michault, A.
影响因子：
5.4
作者：
Tappe, Dennis;Schmidt-Chanasit, Jonas;Stich, August
通讯作者：
Stich, August
影响因子：
0.7
作者：
Inoue, S;Morita, K;Natividad, FF
通讯作者：
Natividad, FF
影响因子：
4.5
作者：
Randrianasolo, Laurence;Raoelina, Yolande;Richard, Vincent
通讯作者：
Richard, Vincent