Histology atlas of the developing mouse heart with emphasis on E11.5 to E18.5.
Histology atlas of the developing mouse heart with emphasis on E11.5 to E18.5.
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DOI：
10.1177/0192623309335060
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发表时间：
2009-06
影响因子：
1.5
通讯作者：
Elmore SA
中科院分区：
文献类型：
--
作者：
Savolainen SM;Foley JF;Elmore SA
在人类中，先天性心脏病是常见的。随着转基因技术的迅速发展，小鼠已成为心血管发育缺陷的主要动物模型。此外，转基因小鼠经常在子宫内死亡，通常是由于心血管发育异常。各种出版物涉及小鼠心脏的特定发育阶段或结构，但尚未获得一个单独的参考文献，该文献逐阶段审查和描述心脏发育事件的解剖学和组织学。本彩色图谱展示了胚胎/胎儿心脏发育，旨在为病理学家和生物医学科学家提供一种工具，用于对发育中小鼠心脏的苏木精和伊红（H&E）染色切片进行详细的组织学评价，重点是胚胎日（E）11.5-18.5。所选图像说明了每个阶段的主要结构和发育事件，并作为确认胚胎/早期胎儿实足年龄的参考材料，并有助于识别任何异常。在引言中对E11.5前心脏发育的文献进行了广泛的综述。虽然这个图集的重点是描述正常小鼠心脏从E11.5到E18.5的解剖学和组织学发育，潜在的胚胎心脏病变与最常见的转基因产前和围产期心脏缺陷的列表进行了讨论。E11.5-15.5和E18.5时心脏的代表性图像见图2-4、6、8和9。完整的一组标记图像（图E11.5-18.5）可参见本期《毒理学病理学》随附的CD。所有数字图像都可以在https://niehsimages.epl-inc.com上在线查看，用户名为“ToxPath”，密码为“胚胎心脏”。
In humans, congenital heart diseases are common. Since the rapid progression of transgenic technologies, the mouse has become the major animal model of defective cardiovascular development. Moreover, genetically modified mice frequently die in utero, commonly due to abnormal cardiovascular development. A variety of publications address specific developmental stages or structures of the mouse heart, but a single reference reviewing and describing the anatomy and histology of cardiac developmental events, stage by stage, has not been available. The aim of this color atlas, which demonstrates embryonic/fetal heart development, is to provide a tool for pathologists and biomedical scientists to use for detailed histological evaluation of hematoxylin and eosin (H&E)-stained sections of the developing mouse heart with emphasis on embryonic days (E) 11.5–18.5. The selected images illustrate the main structures and developmental events at each stage and serve as reference material for the confirmation of the chronological age of the embryo/early fetus and assist in the identification of any abnormalities. An extensive review of the literature covering cardiac development pre-E11.5 is summarized in the introduction. Although the focus of this atlas is on the descriptive anatomic and histological development of the normal mouse heart from E11.5 to E18.5, potential embryonic cardiac lesions are discussed with a list of the most common transgenic pre- and perinatal heart defects. Representative images of hearts at E11.5-15.5 and E18.5 are provided in Figures 2-4, 6, 8, and 9. A complete set of labeled images (Figures E11.5-18.5) is available on the CD enclosed in this issue of Toxicologic Pathology. All digital images can be viewed online at https://niehsimages.epl-inc.com with the username “ToxPath” and the password “embryohearts.”
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