Effects of Voluntary Wheel-Running Types on Hippocampal Neurogenesis and Spatial Cognition in Middle-Aged Mice.
Effects of Voluntary Wheel-Running Types on Hippocampal Neurogenesis and Spatial Cognition in Middle-Aged Mice.
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自愿跑轮类型对中年小鼠海马神经发生和空间认知的影响
DOI：
10.3389/fncel.2018.00177
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发表时间：
2018
影响因子：
5.3
通讯作者：
Lan Y
中科院分区：
文献类型：
--
作者：
Huang YQ;Wu C;He XF;Wu D;He X;Liang FY;Dai GY;Pei Z;Xu GQ;Lan Y
虽然越来越多的证据表明，自愿轮运行促进认知功能，很少有人知道不同类型的自愿轮运行如何影响老年人的认知功能。我们研究了不同类型的自愿轮跑对中年小鼠成年海马神经发生和空间认知的影响。将雄性C57 BL 6和Thy 1-绿色荧光蛋白（GFP）转基因小鼠（13个月）平均分配到以下组之一：（1）T1：无自主轮跑;（2）T2：间歇性自主轮跑;和（3）T3：连续自主轮跑。Thy 1-GFP转基因小鼠用于特异性标记颗粒细胞，因为Thy-1是神经元表达的启动子。行为评估表明，间歇性自愿跑轮可以改善中年小鼠的莫里斯水迷宫表现。BrdU阳性细胞的数量显着高于间歇性和连续自愿车轮运行相比，没有自愿车轮运行。然而，只有间歇性的自愿车轮运行促进新生细胞分化为颗粒细胞，而新生细胞倾向于分化为星形胶质细胞和小胶质细胞的再增殖也在连续自愿车轮运行组增强。这些结果表明，间歇性随意运动可能更有利于提高空间记忆。中年小鼠间歇性自主跑轮也能有效改善海马神经发生。
While increasing evidence demonstrated that voluntary wheel running promotes cognitive function, little is known on how different types of voluntary wheel running affect cognitive function in elderly populations. We investigated the effects of various voluntary wheel-running types on adult hippocampal neurogenesis and spatial cognition in middle-aged mice. Male C57BL6 and Thy1-green fluorescent protein (GFP) transgenic mice (13 months) were equally assigned to one of the following groups: (1) T1: no voluntary wheel running; (2) T2: intermittent voluntary wheel running; and (3) T3: continuous voluntary wheel running. The Thy1-GFP transgenic mice were used to specifically label granule cells, since Thy-1 is a promoter for neuronal expression. Behavioral evaluations suggested that intermittent voluntary wheel running improved Morris water maze performance in middle-aged mice. The number of BrdU-positive cells was significantly higher in both intermittent and continuous voluntary wheel running compared with no voluntary wheel running. However, only intermittent voluntary wheel running facilitated the newborn cells to differentiate into granule cells, while newborn cells tended to differentiate into astrocytes and repopulation of microglia was also enhanced in the continuous voluntary wheel-running group. These results indicated that intermittent voluntary exercise may be more beneficial for enhancing spatial memory. Effective improvement of hippocampal neurogenesis was also caused by intermittent voluntary wheel running in middle-aged mice.
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影响因子：
4.3
作者：
Gebara E;Sultan S;Kocher-Braissant J;Toni N
通讯作者：
Toni N
影响因子：
64.5
作者：
Bonaguidi MA;Wheeler MA;Shapiro JS;Stadel RP;Sun GJ;Ming GL;Song H
通讯作者：
Song H
影响因子：
2.5
作者：
Kronenberg, G;Reuter, K;Kempermann, G
通讯作者：
Kempermann, G
影响因子：
3.3
作者：
Driscoll, I.;Howard, S. R.;Sutherland, R. J.
通讯作者：
Sutherland, R. J.
影响因子：
5.2
作者：
Farioli-Vecchioli, Stefano;Mattera, Andrea;Tirone, Felice
通讯作者：
Tirone, Felice