Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging.
Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging.
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DOI：
10.3389/fnins.2013.00145
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发表时间：
2013
影响因子：
4.3
通讯作者：
Toni N
中科院分区：
文献类型：
--
作者：
Gebara E;Sultan S;Kocher-Braissant J;Toni N
成人海马神经发生导致新神经元的形成，是涉及学习和记忆的大脑可塑性过程。成体神经干细胞或祖细胞的增殖受到多种外在因素（例如经验、疾病或衰老）以及源自神经源性生态位的内在因素的调节。小胶质细胞在齿状回 (DG) 中非常丰富，越来越多的证据表明这些细胞介导炎症诱导的神经发生减少。然而，小胶质细胞在生理条件下神经发生中的作用仍然知之甚少。在这项研究中，我们监测了小胶质细胞和成体海马干/祖细胞在已知分别增加或减少成体神经发生、自主跑步和衰老的生理条件下的增殖。我们发现 DG 中小胶质细胞的数量与颗粒细胞层中干细胞/祖细胞的数量和细胞增殖呈强烈负相关。因此，降低神经祖细胞/神经胶质细胞比例的共培养物表明，小胶质细胞而不是星形胶质细胞减少了祖细胞的数量。总之，这些结果表明，尽管没有炎症刺激，小胶质细胞仍抑制神经干/祖细胞的增殖。
Adult hippocampal neurogenesis results in the formation of new neurons and is a process of brain plasticity involved in learning and memory. The proliferation of adult neural stem or progenitor cells is regulated by several extrinsic factors such as experience, disease or aging and intrinsic factors originating from the neurogenic niche. Microglia is very abundant in the dentate gyrus (DG) and increasing evidence indicates that these cells mediate the inflammation-induced reduction in neurogenesis. However, the role of microglia in neurogenesis in physiological conditions remains poorly understood. In this study, we monitored microglia and the proliferation of adult hippocampal stem/progenitor cells in physiological conditions known to increase or decrease adult neurogenesis, voluntary running and aging respectively. We found that the number of microglia in the DG was strongly inversely correlated with the number of stem/progenitor cells and cell proliferation in the granule cell layer. Accordingly, co-cultures of decreasing neural progenitor/glia ratio showed that microglia but not astroglia reduced the number of progenitor cells. Together, these results suggest that microglia inhibits the proliferation of neural stem/progenitor cells despite the absence of inflammatory stimulus.
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影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
影响因子：
15.1
作者：
Kohman, Rachel A.;DeYoung, Erin K.;Bhattacharya, Tushar K.;Peterson, Lindsey N.;Rhodes, Justin S.
通讯作者：
Rhodes, Justin S.
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13.9
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Kriegstein A;Alvarez-Buylla A
通讯作者：
Alvarez-Buylla A
影响因子：
15.1
作者：
Kohman, Rachel A.;Rhodes, Justin S.
通讯作者：
Rhodes, Justin S.