An Advanced Multifunctional Hydrogel-Based Dressing for Wound Monitoring and Drug Delivery.
An Advanced Multifunctional Hydrogel-Based Dressing for Wound Monitoring and Drug Delivery.
复制标题
DOI：
10.1002/adhm.201700718
复制
发表时间：
2017-10
影响因子：
10
通讯作者：
Akbari M
中科院分区：
文献类型：
--
作者：
Mirani B;Pagan E;Currie B;Siddiqui MA;Hosseinzadeh R;Mostafalu P;Zhang YS;Ghahary A;Akbari M
伤口管理是一项重大的全球性挑战，由于糖尿病、肥胖症和人口老龄化等慢性疾病的快速增长，伤口管理给医疗保健系统带来了巨大的经济负担。检测病原性感染和在伤口部位释放药物的能力对于方便的患者护理是至关重要的。在此，本研究提出了一种先进的多功能敷料（GelDerm），能够比色测量pH值，细菌感染的指标，并在伤口部位释放抗生素。本研究证明了GelDerm使用体外和离体试验检测细菌感染的能力，其准确度与市售系统相当。与数字图像采集硬件（如智能手机）的无线接口可作为定量手段，使患者能够在家中记录伤口状况，并将信息转发给医疗保健人员，以遵循治疗策略。此外，该敷料与市售贴片整合在一起，可以放置在伤口上，而不会产生化学或物理刺激。这项研究证明了GelDerm通过持续释放抗生素来根除细菌的能力。所提出的技术在管理由创伤、手术或糖尿病引起的慢性和急性损伤方面具有很大的前景。
Wound management is a major global challenge and poses a significant financial burden to the healthcare system due to the rapid growth of chronic diseases such as diabetes, obesity, and aging population. The ability to detect pathogenic infections and release drug at the wound site is of the utmost importance to expedient patient care. Herein, this study presents an advanced multifunctional dressing (GelDerm) capable of colorimetric measurement of pH, an indicator of bacterial infection, and release of antibiotic agents at the wound site. This study demonstrates the ability of GelDerm to detect bacterial infections using in vitro and ex vivo tests with accuracies comparable to the commercially available systems. Wireless interfaces to digital image capture hardware such as smartphones serve as a means for quantitation and enable the patient to record the wound condition at home and relay the information to the healthcare personnel for following treatment strategies. Additionally, the dressing is integrated within commercially available patches and can be placed on the wound without chemical or physical irritation. This study demonstrates the ability of GelDerm to eradicate bacteria by the sustained release of antibiotics. The proposed technology holds great promise in managing chronic and acute injuries caused by trauma, surgery, or diabetes.
登录
查看更多内容
影响因子：
17.1
作者：
Koh A;Kang D;Xue Y;Lee S;Pielak RM;Kim J;Hwang T;Min S;Banks A;Bastien P;Manco MC;Wang L;Ammann KR;Jang KI;Won P;Han S;Ghaffari R;Paik U;Slepian MJ;Balooch G;Huang Y;Rogers JA
通讯作者：
Rogers JA
影响因子：
2.8
作者：
Ghorbanian, Setareh;Qasaimeh, Mohammad A.;Juncker, David
通讯作者：
Juncker, David
影响因子：
2.7
作者：
Maral, T;Borman, H;Haberal, M
通讯作者：
Haberal, M
影响因子：
41.2
作者：
通讯作者：
--
影响因子：
11.2
作者：
Lavorgna, Marino;Piscitelli, Filomena;Buonocore, Giovanna G.
通讯作者：
Buonocore, Giovanna G.