PUMA, a critical mediator of cell death--one decade on from its discovery.
PUMA, a critical mediator of cell death--one decade on from its discovery.
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DOI：
10.2478/s11658-012-0032-5
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发表时间：
2012-12
影响因子：
8.3
通讯作者：
Kiliańska ZM
中科院分区：
文献类型：
--
作者：
Hikisz P;Kiliańska ZM
p53上调的细胞凋亡调节因子（p53 upregulated modulator of apoptosis，p53）是Bcl-2家族的仅BH 3亚组的促细胞凋亡成员。它是p53依赖性和p53非依赖性细胞凋亡的关键介质，10年前被发现。该基因定位于19号染色体的长臂，这是一个在大量人类癌症中经常缺失的区域。由于其直接结合Bcl-2家族的已知抗凋亡成员的能力，CD 3A介导凋亡。它主要定位于线粒体。通过BH 3结构域将BCLA与Bcl-2家族的抑制性成员（Bcl-2样蛋白）结合似乎是诱导细胞凋亡的关键调节步骤。其导致蛋白Bax和/或巴克的置换。随后是它们的活化和线粒体膜上孔样结构的形成，其使线粒体外膜透化，导致线粒体功能障碍和半胱天冬酶活化。它参与了大量的生理和病理过程，包括免疫反应、癌症、神经退行性疾病以及细菌和病毒感染。
PUMA (p53 upregulated modulator of apoptosis) is a pro-apoptotic member of the BH3-only subgroup of the Bcl-2 family. It is a key mediator of p53-dependent and p53-independent apoptosis and was identified 10 years ago. The PUMA gene is mapped to the long arm of chromosome 19, a region that is frequently deleted in a large number of human cancers. PUMA mediates apoptosis thanks to its ability to directly bind known anti-apoptotic members of the Bcl-2 family. It mainly localizes to the mitochondria. The binding of PUMA to the inhibitory members of the Bcl-2 family (Bcl-2-like proteins) via its BH3 domain seems to be a critical regulatory step in the induction of apoptosis. It results in the displacement of the proteins Bax and/or Bak. This is followed by their activation and the formation of pore-like structures on the mitochondrial membrane, which permeabilizes the outer mitochondrial membrane, leading to mitochondrial dysfunction and caspase activation. PUMA is involved in a large number of physiological and pathological processes, including the immune response, cancer, neurodegenerative diseases and bacterial and viral infections.
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影响因子：
16
作者：
Charvet C;Wissler M;Brauns-Schubert P;Wang SJ;Tang Y;Sigloch FC;Mellert H;Brandenburg M;Lindner SE;Breit B;Green DR;McMahon SB;Borner C;Gu W;Maurer U
通讯作者：
Maurer U
影响因子：
5.6
作者：
Day, Catherine L.;Smits, Callum;Hinds, Mark G.
通讯作者：
Hinds, Mark G.
影响因子：
--
作者：
Elkholi, Rana;Floros, Konstantinos V;Chipuk, Jerry E
通讯作者：
Chipuk, Jerry E
影响因子：
9
作者：
通讯作者：
--
影响因子：
64.8
作者：
Gavathiotis, Evripidis;Suzuki, Motoshi;Davis, Marguerite L.;Pitter, Kenneth;Bird, Gregory H.;Katz, Samuel G.;Tu, Ho-Chou;Kim, Hyungjin;Cheng, Emily H. -Y.;Tjandra, Nico;Walensky, Loren D.
通讯作者：
Walensky, Loren D.