Amniotic Epithelial Cells: A New Tool to Combat Aging and Age-Related Diseases?
Amniotic Epithelial Cells: A New Tool to Combat Aging and Age-Related Diseases?
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DOI：
10.3389/fcell.2016.00135
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发表时间：
2016
影响因子：
5.5
通讯作者：
Barboni B
中科院分区：
文献类型：
--
作者：
Di Germanio C;Bernier M;de Cabo R;Barboni B
老年人的数量正在以前所未有的速度增长，预计老龄化人口的增加将对与年龄有关的疾病的发病率和与保健有关的费用产生直接影响。因此，当务之急是开发新的工具来防治和减缓与年龄有关的疾病。再生医学是维持生命后期健康和功能的一种有前途的策略;然而，基于干细胞的治疗面临着一些挑战，包括排斥反应和肿瘤转化。作为替代方案，胎盘提供了胎儿干细胞的非凡来源，包括羊膜上皮细胞（AEC），其保留了胚胎干细胞的一些特征，但显示出低免疫原性，以及免疫调节和抗炎活性。由于这些特性，AEC已被广泛用于再生医学。这一观点强调了移植的AEC触发的不同机制，这些机制可能对抗衰老疗法有用，其中包括：年龄相关环境中组织再生的移植和分化，对抗“炎症”的抗炎行为，抗肿瘤活性，直接寿命和健康寿命延长特性，以及可能以异时共生的方式恢复活力。在这里，我们批判性地讨论了基于AEC的治疗在年龄相关疾病中的益处和局限性。
The number of elderly people is growing at an unprecedented rate and this increase of the aging population is expected to have a direct impact on the incidence of age-related diseases and healthcare-associated costs. Thus, it is imperative that new tools are developed to fight and slow age-related diseases. Regenerative medicine is a promising strategy for the maintenance of health and function late in life; however, stem cell-based therapies face several challenges including rejection and tumor transformation. As an alternative, the placenta offers an extraordinary source of fetal stem cells, including the amniotic epithelial cells (AECs), which retain some of the characteristics of embryonic stem cells, but show low immunogenicity, together with immunomodulatory and anti-inflammatory activities. Because of these characteristics, AECs have been widely utilized in regenerative medicine. This perspective highlights different mechanisms triggered by transplanted AECs that could be potentially useful for anti-aging therapies, which include: Graft and differentiation for tissue regeneration in age-related settings, anti-inflammatory behavior to combat “inflammaging,” anti-tumor activity, direct lifespan and healthspan extension properties, and possibly rejuvenation in a manner reminiscent of heterochronic parabiosis. Here, we critically discuss benefits and limitation of AECs-based therapies in age-related diseases.
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影响因子：
4.5
作者：
Liang, Hongsheng;Guan, Dong;Zhang, Xiangtong
通讯作者：
Zhang, Xiangtong
影响因子：
3.4
作者：
Hemberger, Myriam
通讯作者：
Hemberger, Myriam
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
2.7
作者：
Banas, Richard Allan;Trumpower, Catherine;Zeevi, Adriana
通讯作者：
Zeevi, Adriana
影响因子：
3.9
作者：
Dong, Wanli;Chen, Haiyun;Hui, Guozhen
通讯作者：
Hui, Guozhen