Recurring ethanol exposure induces disinhibited courtship in Drosophila.
Recurring ethanol exposure induces disinhibited courtship in Drosophila.
复制标题
DOI：
10.1371/journal.pone.0001391
复制
发表时间：
2008-01-02
期刊：
影响因子：
3.7
通讯作者：
Han KA
中科院分区：
文献类型：
--
作者：
Lee HG;Kim YC;Dunning JS;Han KA
Alcohol has a strong causal relationship with sexual arousal and disinhibited sexual behavior in humans; however, the physiological support for this notion is largely lacking and thus a suitable animal model to address this issue is instrumental. We investigated the effect of ethanol on sexual behavior in Drosophila. Wild-type males typically court females but not males; however, upon daily administration of ethanol, they exhibited active intermale courtship, which represents a novel type of behavioral disinhibition. The ethanol-treated males also developed behavioral sensitization, a form of plasticity associated with addiction, since their intermale courtship activity was progressively increased with additional ethanol experience. We identified three components crucial for the ethanol-induced courtship disinhibition: the transcription factor regulating male sex behavior Fruitless, the ABC guanine/tryptophan transporter White and the neuromodulator dopamine. fruitless mutant males normally display conspicuous intermale courtship; however, their courtship activity was not enhanced under ethanol. Likewise, white males showed negligible ethanol-induced intermale courtship, which was not only reinstated but also augmented by transgenic White expression. Moreover, inhibition of dopamine neurotransmission during ethanol exposure dramatically decreased ethanol-induced intermale courtship. Chronic ethanol exposure also affected a male's sexual behavior toward females: it enhanced sexual arousal but reduced sexual performance. These findings provide novel insights into the physiological effects of ethanol on sexual behavior and behavioral plasticity.
登录
查看更多内容
影响因子：
2
作者：
Diegelmann, S;Zars, M;Zars, T
通讯作者：
Zars, T
DOI：
10.1097/01.alc.0000141817.15993.98
发表时间：
2004-10-01
影响因子：
3.2
作者：
Berger, KH;Heberlein, U;Moore, MS
通讯作者：
Moore, MS
影响因子：
56.9
作者：
Ferveur, JF;Savarit, F;Jallon, JM
通讯作者：
Jallon, JM
影响因子：
3.4
作者：
Godenschwege, TA;Reisch, D;Buchner, E
通讯作者：
Buchner, E
影响因子：
2.3
作者：
Boileau, I;Assaad, JM;Dagher, A
通讯作者：
Dagher, A