Event segmentation protects emotional memories from competing experiences encoded close in time.
Event segmentation protects emotional memories from competing experiences encoded close in time.
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DOI：
10.1038/s41562-018-0317-4
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发表时间：
2018-04
影响因子：
29.9
通讯作者：
Phelps EA
中科院分区：
文献类型：
--
作者：
Dunsmoor JE;Kroes MCW;Moscatelli CM;Evans MD;Davachi L;Phelps EA
恐惧记忆的特点是它们的持久性和对新经历的强烈抵制。我们考虑了这种持久性是否涉及记忆分割的过程，将竞争的经验分开。为了解决这个问题，我们使用了一个情绪学习任务，旨在测量识别记忆的类别样本编码在竞争的经验，恐惧条件反射和灭绝。在这里，我们表明，人们认识到更多的恐惧条件的范例在空调编码比概念上相关的范例编码后立即感知事件边界分离空调灭绝。选择性情景记忆依赖于一段时间的巩固，一个明确的竞争经验之间的休息，是无关的会话内唤醒或明确实现从条件反射到灭绝的过渡。总的来说，这些研究结果表明，事件边界引导选择性巩固，以牺牲相关但冲突的信息后不久经历的记忆中的情感信息的优先级。我们提出了一个模型，事件边界分叉相关的记忆痕迹不兼容的经验。这与整合相关经验进行自适应泛化的机制形成鲜明对比，并揭示了一种潜在的独特组织，通过这种组织，竞争记忆被自适应地分割，以选择和保护新生的恐惧记忆免受直接干扰源的影响。
Fear memories are characterized by their permanence and a fierce resistance to unlearning by new experiences. We considered whether this durability involves a process of memory segmentation that separates competing experiences. To address this question, we used an emotional learning task designed to measure recognition memory for category exemplars encoded during competing experiences of fear-conditioning and extinction. Here we show that people recognized more fear-conditioned exemplars encoded during conditioning than conceptually related exemplars encoded immediately after a perceptual event boundary separating conditioning from extinction. Selective episodic memory depended on a period of consolidation, an explicit break between competing experiences, and was unrelated to within-session arousal or the explicit realization of a transition from conditioning to extinction. Collectively, these findings suggest that event boundaries guide selective consolidation to prioritize emotional information in memory—at the expense of related but conflicting information experienced shortly thereafter. We put forward a model whereby event boundaries bifurcate related memory traces for incompatible experiences. This stands in contrast to a mechanism that integrates related experiences for adaptive generalization, and reveals a potentially distinct organization by which competing memories are adaptively segmented to select and protect nascent fear memories from immediate sources of interference.
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影响因子：
9.2
作者：
Adolphs, Ralph
通讯作者：
Adolphs, Ralph
影响因子：
3
作者：
Gershman, Samuel J.;Jones, Carolyn E.;Niv, Yael
通讯作者：
Niv, Yael
影响因子：
2.7
作者：
DuBrow, Sarah;Davachi, Lila
通讯作者：
Davachi, Lila
DOI：
10.1073/pnas.0404965101
发表时间：
2004-09-07
影响因子：
11.1
作者：
Gallistel, CR;Fairhurst, S;Balsam, P
通讯作者：
Balsam, P
影响因子：
16.2
作者：
Ezzyat Y;Davachi L
通讯作者：
Davachi L