Therapeutic effects of an oral gonadotropin-releasing hormone receptor antagonist, relugolix, on preventing premature ovulation in mild ovarian stimulation for IVF.
Therapeutic effects of an oral gonadotropin-releasing hormone receptor antagonist, relugolix, on preventing premature ovulation in mild ovarian stimulation for IVF.
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DOI：
10.1002/rmb2.12422
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发表时间：
2022-01
影响因子：
3.4
通讯作者：
Sugiyama R
中科院分区：
文献类型：
--
作者：
Nakao K;Kuroda K;Horikawa T;Moriyama A;Juen H;Itakura A;Watanabe H;Takamizawa S;Ojiro Y;Nakagawa K;Sugiyama R
新的口服促性腺激素释放激素受体(GnRH)拮抗剂瑞洛格雷能否作为GnRH拮抗剂注射的替代排卵抑制剂？这项单中心、横断面的回顾性研究比较了2019年3月至2020年1月期间，在轻度卵巢刺激后，注射40 mg雷洛格利克斯(雷卢戈利组)或0.25毫克醋酸加尼利克斯或醋酸西曲利克斯(注射组)的提前排卵率和IVF治疗的临床结果。在247例(256个体外受精周期)的不孕妇女中，对223例(230个周期)的≤进行了评估。在瑞罗格列酮组和注射组中，我们分别比较了促黄体生成素释放激素拮抗剂在促黄体生成素激动期前使用后的第104和85个周期(促黄体生成素水平和110mIU/ml)和促黄体生成素高峰期间的22和19个周期(促黄体生成素水平≥为10mIU/ml)。促黄体生成素高峰前，两组的排卵率均很低(p=0.838)，而在促黄体生成素高峰期间，使用瑞罗格列酮的周期排卵率为40.9%，高于注射组不排卵的排卵率(p=0.002)。两组在胚胎培养结果和妊娠结局方面无显著差异。瑞洛格雷虽有较强的排卵抑制作用，但当出现促黄体生成素高峰时，其抑制排卵作用不明显。
Can relugolix, a novel oral gonadotropin‐releasing hormone receptor (GnRH) antagonist, function as an alternative ovulation inhibitor to GnRH antagonist injections? This single‐center, cross‐sectional retrospective study compared premature ovulation rates and clinical outcomes in IVF treatment after mild ovarian stimulation with 40 mg of relugolix (relugolix group) or 0.25‐mg injections of ganirelix acetate or cetrorelix acetate (injection group) between March 2019 and January 2020. Of 247 infertile women (256 IVF cycles) aged ≤42 years, 223 women (230 cycles) were evaluated. In the relugolix and injection groups, we compared 104 and 85 cycles after GnRH antagonist use before the LH surge (LH levels <10 mIU/ml) and 22 and 19 cycles during the LH surge (LH levels ≥10 mIU/ml), respectively. Before the LH surge, the ovulation rates in the two groups were very low (p = 0.838), however; during the LH surge, the cycles using relugolix had a high ovulation rate of 40.9% compared with no ovulation in the injection group (p = 0.002). There were no significant differences in embryo culture findings and pregnancy outcomes between the two groups. Although relugolix had a high ovulation suppressive effect, when the LH surge occurred, its effect was insufficient.
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影响因子：
4
作者：
Kawachiya, Satoshi;Matsumoto, Tsunekazu;Kato, Osamu
通讯作者：
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影响因子：
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作者：
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DOI：
10.1111/1471-0528.14622
发表时间：
2017-06-01
影响因子：
5.8
作者：
Dong, J.;Wang, Y.;Kuang, Y. P.
通讯作者：
Kuang, Y. P.
影响因子：
6.7
作者：
Osuga, Yutaka;Seki, Yoshifumi;Terakawa, Naoki
通讯作者：
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影响因子：
3.4
作者：
Nakagawa, Koji;Nishi, Yayoi;Sugiyama, Rikikazu
通讯作者：
Sugiyama, Rikikazu