Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies.
Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies.
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DOI：
10.1371/journal.pone.0014126
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发表时间：
2010-11-29
期刊：
影响因子：
3.7
通讯作者：
Sørensen TI
中科院分区：
文献类型：
--
作者：
Andersen LG;Angquist L;Eriksson JG;Forsen T;Gamborg M;Osmond C;Baker JL;Sørensen TI
低出生体重和高儿童体重指数(BMI)都与成年后患冠心病(CHD)的风险增加有关。我们研究了出生体重和儿童体重指数与成年后患冠心病风险的个体和联合关系。出生于1924年至1976年的216,771名丹麦和芬兰人的出生体重和7岁时的BMI可以获得。与国家住院和死因登记相联系，在25岁后长达33年的随访中(中位数 = 为24年)，确定了8,805例冠心病事件。采用基于限制性三次样条法的COX回归进行分析。以出生体重中位数3.4 kg为参考值，发现出生体重与冠心病之间存在非线性关系。在队列之间、男性和女性之间没有显著差异，这种联系也不会因为童年的BMI而改变。当出生体重在3.4 kg以下时，患冠心病的风险呈线性增加，2 kg时达到1.28(95%可信限：1.13~1.44)。超过3.4公斤，这种联系减弱，而从大约4公斤开始，几乎没有联系。出生7岁时的BMI与患冠心病的风险呈显著正相关，而且这种关系不会因出生体重而改变。出生体重为2.5 kg、BMI为17.7 kg/m2的7岁儿童的超额危险度为44%(95%CI：30%~59%)，而出生体重(3.4 kg)和BMI中值(15.3 kg/m2)的超额风险为44%。出生体重和7岁时的BMI似乎与成年后患冠心病的风险独立相关。从公共卫生的角度来看，我们建议特别关注出生体重低于平均体重并伴有儿童期超重的儿童。
Low birth weight and high childhood body mass index (BMI) is each associated with an increased risk of coronary heart disease (CHD) in adult life. We studied individual and combined associations of birth weight and childhood BMI with the risk of CHD in adulthood. Birth weight and BMI at age seven years were available in 216,771 Danish and Finnish individuals born 1924–1976. Linkage to national registers for hospitalization and causes of death identified 8,805 CHD events during up to 33 years of follow-up (median = 24 years) after age 25 years. Analyses were conducted with Cox regression based on restricted cubic splines. Using median birth weight of 3.4 kg as reference, a non-linear relation between birth weight and CHD was found. It was not significantly different between cohorts, or between men and women, nor was the association altered by childhood BMI. For birth weights below 3.4 kg, the risk of CHD increased linearly and reached 1.28 (95% confidence limits: 1.13 to 1.44) at 2 kg. Above 3.4 kg the association weakened, and from about 4 kg there was virtually no association. BMI at age seven years was strongly positively associated with the risk of CHD and the relation was not altered by birth weight. The excess risk in individuals with a birth weight of 2.5 kg and a BMI of 17.7 kg/m2 at age seven years was 44% (95% CI: 30% to 59%) compared with individuals with median values of birth weight (3.4 kg) and BMI (15.3 kg/m2). Birth weight and BMI at age seven years appeared independently associated with the risk of CHD in adulthood. From a public health perspective we suggest that particular attention should be paid to children with a birth weight below the average in combination with excess relative weight in childhood.
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影响因子：
3.7
作者：
Andersen, Lise Geisler;Angquist, Lars;Baker, Jennifer L.
通讯作者：
Baker, Jennifer L.
影响因子：
7.1
作者：
Huxley, Rachel;Owen, Christopher G.;Collins, Rory
通讯作者：
Collins, Rory
影响因子：
4.9
作者：
Falkstedt, D.;Hemmingsson, T.;Lundberg, I.
通讯作者：
Lundberg, I.
影响因子：
7.1
作者：
Gunnarsdottir, I;Birgisdottir, BE;Benediktsson, R
通讯作者：
Benediktsson, R
影响因子：
--
作者：
Forsén, T;Eriksson, JG;Barker, DJP
通讯作者：
Barker, DJP