Focal limbic sources create the large slow oscillations of the EEG in human deep sleep.
Focal limbic sources create the large slow oscillations of the EEG in human deep sleep.
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DOI：
10.1016/j.sleep.2021.07.028
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发表时间：
2021-09
期刊：
影响因子：
4.8
通讯作者：
Tucker DM
中科院分区：
文献类型：
--
作者：
Morgan KK;Hathaway E;Carson M;Fernandez-Corazza M;Shusterman R;Luu P;Tucker DM
对人类脑电图 (EEG) 的初步观察将深度睡眠 (N3) 期间脑电图的慢振荡 (SO) 解释为反映了广泛的表面负行波，该行波起源于额叶区域并在新皮质中传播。然而，用高密度阵列绘制 SO 表明，在额叶负场时，脑电图中同时出现后正电压场，典型的反转点（表观源）位于颞叶周围。隔夜收集了 10 名健康年轻人的 256 通道脑电图记录。使用每个参与者自己的结构 MRI 创建个体头部电导率模型。然后在 N3 期间进行 SO 的源定位。电源定位模型证实，这些大波是由腹侧边缘皮层（包括内侧颞叶皮层和尾侧眶额皮层）内的局灶性放电产生的。尽管深度睡眠的功能神经生理学涉及边缘系统和新皮质网络之间的相互作用，但深度睡眠的大脑电图偏转不是由外侧新皮质中的分布式行波产生的，而是由相对集中的边缘放电产生的。
Initial observations with the human electroencephalogram (EEG) have interpreted slow oscillations (SOs) of the EEG during deep sleep (N3) as reflecting widespread surface-negative traveling waves that originate in frontal regions and propagate across the neocortex. However, mapping SOs with a high-density array shows the simultaneous appearance of posterior positive voltage fields in the EEG at the time of the frontal-negative fields, with the typical inversion point (apparent source) around the temporal lobe. Overnight 256-channel EEG recordings were gathered from 10 healthy young adults. Individual head conductivity models were created using each participant’s own structural MRI. Source localization of SOs during N3 was then performed. Electrical source localization models confirmed that these large waves were created by focal discharges within the ventral limbic cortex, including medial temporal and caudal orbitofrontal cortex. Although the functional neurophysiology of deep sleep involves interactions between limbic and neocortical networks, the large EEG deflections of deep sleep are not created by distributed traveling waves in lateral neocortex but instead by relatively focal limbic discharges.
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