An Adenosine Triphosphate-Responsive Autocatalytic Fenton Nanoparticle for Tumor Ablation with Self-Supplied H2O2 and Acceleration of Fe(III)/Fe(II) Conversion.
An Adenosine Triphosphate-Responsive Autocatalytic Fenton Nanoparticle for Tumor Ablation with Self-Supplied H2O2 and Acceleration of Fe(III)/Fe(II) Conversion.
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一种三磷酸腺苷响应自催化芬顿纳米颗粒，用于通过自供 H2O2 消融肿瘤并加速 Fe(III)/Fe(II) 转化。
DOI：
10.1021/acs.nanolett.8b03178
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发表时间：
2018-11
期刊：
影响因子：
10.8
通讯作者：
Zhang Xian-Zheng
中科院分区：
文献类型：
--
作者：
Zhang Lu;Wan Shuang-Shuang;Li Chu-Xin;Xu Lu;Cheng Han;Zhang Xian-Zheng
化学动力学疗法(CDT)可以在过氧化氢和强大的催化剂存在下，通过Fenton反应有效地破坏肿瘤细胞。然而，它也面临着严峻的挑战，包括过氧化氢的数量有限和催化剂的低效。本文设计并合成了一种三磷酸腺苷(ATP)响应型自催化Fenton纳米系统(Gox@ZIF@MPN)，将葡萄糖氧化酶(GOx)固定在分子筛咪唑骨架(ZIF)中，然后包覆金属多酚网络(MPN)，用于自供H_2O_2和TA介导的加速Fe(III)/Fe(II)转化的肿瘤消融。在ATP过表达的肿瘤细胞中，Gox@ZIF@MPN的外壳MPN被降解为Fe(III)和单宁酸(TA)，内部的Gox暴露。然后，Gox与内源葡萄糖反应生成大量的H_2O_2，TA将Fe(III)还原为Fe(II)，这对Fenton反应是一种更具活力的催化剂。随后，自身产生的过氧化氢被Fe(II)催化生成剧毒的羟基自由基(·OH)和Fe(III)。生成的低催化活性的Fe(III)在TA的作用下被快速还原为活性Fe(II)，从而加速了Fe(III)/Fe(II)的转化，从而保证了高效的Fenton反应介导的CDT。这种自催化的Fenton纳米系统可能为有效的肿瘤治疗提供一个很好的范例。
Chemodynamic therapy (CDT) can efficiently destroy tumor cells via Fenton reaction in the presence of H2O2 and a robust catalyst. However, it has faced severe challenges including the limited amounts of H2O2 and inefficiency of catalysts. Here, an adenosine triphosphate (ATP)-responsive autocatalytic Fenton nanosystem (GOx@ZIF@MPN), incorporated with glucose oxidase (GOx) in zeolitic imidazolate framework (ZIF) and then coated with metal polyphenol network (MPN), was designed and synthesized for tumor ablation with self-supplied H2O2 and TA-mediated acceleration of Fe(III)/Fe(II) conversion. In the ATP-overexpressed tumor cells, the outer shell MPN of GOx@ZIF@MPN was degraded into Fe(III) and tannic acid (TA) and the internal GOx was exposed. Then, GOx reacted with the endogenous glucose to produce plenty of H2O2, and TA reduced Fe(III) to Fe(II), which is a much more vigorous catalyst for the Fenton reaction. Subsequently, self-produced H2O2 was catalyzed by Fe(II) to generate highly toxic hydroxyl radical (•OH) and Fe(III). The produced Fe(III) with low catalytic activity was quickly reduced to reactive Fe(II) mediated by TA, forming an accelerated Fe(III)/Fe(II) conversion to guarantee efficient Fenton reaction-mediated CDT. This autocatalytic Fenton nanosystem might provide a good paradigm for effective tumor treatment.
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