Behind the opaque curtain: A 20-year longitudinal study of dissociative and first-rank symptoms in schizophrenia-spectrum psychoses, other psychoses and non-psychotic disorders.
Behind the opaque curtain: A 20-year longitudinal study of dissociative and first-rank symptoms in schizophrenia-spectrum psychoses, other psychoses and non-psychotic disorders.
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DOI：
10.1016/j.schres.2020.07.019
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发表时间：
2020-09
影响因子：
4.5
通讯作者：
Rosen C
中科院分区：
文献类型：
--
作者：
Humpston C;Harrow M;Rosen C
人格解体和现实解体目前被认为是不同于精神分裂症谱系精神病的一级症状（FRS）的诊断。然而，这些症状的生活经历在现象学上可能非常相似。探讨不同类型精神病和非精神病患者的人格解体、现实解体与FRS之间的相互关系。芝加哥随访研究是一项前瞻性纵向研究项目，旨在研究精神疾病的精神病理学和恢复，由555名参与者组成，这些参与者在索引住院时招募，并在大约2年、4.5年、7.5年、10年、15年和20年后的6个随访时间点进行研究。主要临床指标是人格解体、现实解体和施奈德FRS，在指标住院和每次后续随访时测量。62.8%的参与者至少有四次随访。三个诊断组的人格解体、现实感丧失和一级症状的病程和慢性程度存在显着差异。对于整个样本，在2年、4.5年和7.5年的随访时间点，现实解体与FRS显著相关，而从10年随访到20年随访，人格解体与FRS相关。在精神分裂症患者中，整体人格解体更常与被动现象相关，而现实解体更常与整体妄想相关。在随访中，时间对人格解体、现实解体和FRS之间的关联也有显著影响。人格解体和现实解体应被视为与FRS精神病理学沿着连续体相关的转诊断现象，尽管它们与精神分裂症谱系精神病更密切相关。
Depersonalization and derealization are currently considered diagnostically distinct from first-rank symptoms (FRS) seen in schizophrenia-spectrum psychoses. Nevertheless, the lived experiences of these symptoms can be very similar phenomenologically. To investigate the interrelationships between depersonalization, derealization and FRS in patients with different types of psychotic and non-psychotic diagnoses. The Chicago Follow-up Study was a prospective longitudinal research programme designed to study psychopathology and recovery in psychiatric disorders consisting of 555 participants, who were recruited at index hospitalization and studied over six follow-up timepoints at approximately 2, 4.5, 7.5, 10, 15, and 20 years later. The primary clinical indices were depersonalization, derealization and Schneiderian FRS that were measured at index hospitalisation and at each subsequent follow-up. 62.8% of participants had at least four follow-ups. There were significant differences in the course and chronicity of depersonalization, derealization and first-rank symptoms across the three diagnostic groups. For the whole sample, derealization was significantly associated with FRS at 2-, 4.5- and 7.5-year follow-up timepoints whereas depersonalization was related to FRS from 10-year follow-up to 20-year follow-up. In patients with schizophrenia, overall depersonalization was more often associated with passivity phenomena whereas derealization was more often associated with overall delusions. There was also a significant effect of time on the associations between depersonalization, derealization and FRS across follow-ups. Depersonalization and derealization should be viewed as transdiagnostic phenomena that are associated with FRS psychopathology along a continuum, although they are more closely associated with schizophrenia-spectrum psychoses.
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影响因子：
3.8
作者：
Giersch A;Mishara AL
通讯作者：
Mishara AL
影响因子：
2.4
作者：
Humpston, Clara S.;Walsh, Eamonn;Deeley, Quinton
通讯作者：
Deeley, Quinton
影响因子：
1.9
作者：
BERNSTEIN, EM;PUTNAM, FW
通讯作者：
PUTNAM, FW
影响因子：
6.6
作者：
Longden, Eleanor;Branitsky, Alison;Varese, Filippo
通讯作者：
Varese, Filippo
DOI：
10.1192/bjp.100.421.838
发表时间：
1954-01-01
期刊：
JOURNAL OF MENTAL SCIENCE
影响因子：
--
作者：
ACKNER, B
通讯作者：
ACKNER, B