A Significant Positive Association of Vitamin D Deficiency with Coronary Artery Calcification among Middle-aged Men: For the ERA JUMP Study.
A Significant Positive Association of Vitamin D Deficiency with Coronary Artery Calcification among Middle-aged Men: For the ERA JUMP Study.
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DOI：
10.1080/07315724.2015.1118651
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发表时间：
2016-09
影响因子：
3.5
通讯作者：
Sekikawa A
中科院分区：
文献类型：
--
作者：
Lee S;Ahuja V;Masaki K;Evans RW;Barinas-Mitchell EJ;Ueshima H;Shin C;Choo J;Hassen L;Edmundowicz D;Kuller LH;Willcox B;Sekikawa A
尽管在横断面研究和前瞻性研究中都证实了维生素D缺乏与冠心病的显著正相关，但只有少数研究调查了维生素D缺乏与亚临床动脉粥样硬化的关系。我们研究了维生素D缺乏是否与亚临床动脉粥样硬化有关，通过无症状成人冠状动脉钙化（CAC）来测量。在一项基于人群的横断面研究中，195名年龄在40至49岁之间无心血管疾病的男性被随机选择（98名白种人和97名日裔美国男性）。采用液相色谱-串联质谱法测定血清维生素d。CAC通过电子束计算机断层扫描检测，采用标准化协议，并在匹兹堡大学使用Agatston的方法集中读取。为了研究维生素D缺乏（定义为25(OH)D<20 ng/mL）和CAC（定义为Agatston评分≥10）之间的关系，我们使用了多变量logistic回归模型。CAC和维生素D缺乏症患病率分别为27.2%和10.3%。患有CAC的参与者年龄明显较大，BMI明显较高，吸烟率也较高。在调整传统心血管危险因素后，CAC患者维生素D缺乏症的可能性是其3.31倍（OR=3.31, 95%CI 1.12-9.77）。在这项以健康中年男性为基础的人群研究中，维生素D缺乏与CAC存在显著正相关。
Although a significant positive association of vitamin D deficiency with coronary heart disease has been demonstrated in cross-sectional as well as prospective studies, only a few studies have examined the association of vitamin D deficiency with subclinical atherosclerosis. We examined whether vitamin D deficiency is associated with subclinical atherosclerosis, as measured by coronary artery calcification (CAC) in asymptomatic adults. In a population-based cross-sectional study, 195 men aged 40 to 49 years without cardiovascular disease were randomly selected (98 Caucasian and 97 Japanese-American men). A liquid-chromatography-tandem-mass-spectrometry was utilized to measure serum vitamin D. CAC was examined by electron-beam-computed-tomography using standardized protocols and read centrally at the University of Pittsburgh using the Agatston’s methods. To investigate an association between vitamin D deficiency (defined as 25(OH)D<20 ng/mL) and CAC (defined as Agatston score ≥10), we utilized multivariable logistic regression models. Prevalence of CAC and vitamin D deficiency was 27.2% and 10.3%, respectively. Participants with CAC were significantly older, had significantly higher BMI, and had higher rates of smoking. Those with CAC were 3.31 times likely to be vitamin D deficient, after adjusting for traditional cardiovascular risk factors (OR=3.31, 95%CI 1.12-9.77). In this population-based study of healthy middle-aged men, vitamin D deficiency had a significant positive association with the presence of CAC.
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影响因子：
9.3
作者：
Leopold JA
通讯作者：
Leopold JA
影响因子：
--
作者：
Melamed, Michal L.;Michos, Erin D.;Post, Wendy;Astor, Brad
通讯作者：
Astor, Brad
DOI：
10.1016/j.jsbmb.2009.11.002
发表时间：
2010-02-15
影响因子：
4.1
作者：
Chen, Songcang;Law, Christopher S.;Gardner, David G.
通讯作者：
Gardner, David G.
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
DETRANO, R
影响因子：
4.4
作者：
Boonstra, A;Barrat, FJ;O'Garra, A
通讯作者：
O'Garra, A