Prenatal phthalate exposure measurement: A comparison of metabolites quantified in prenatal maternal urine and newborn's meconium.
Prenatal phthalate exposure measurement: A comparison of metabolites quantified in prenatal maternal urine and newborn's meconium.
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DOI：
10.1016/j.scitotenv.2021.148898
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发表时间：
2021-11-20
期刊：
影响因子：
--
通讯作者：
Newschaffer CJ
中科院分区：
文献类型：
--
作者：
Mathew L;Snyder NW;Lyall K;Lee BK;McClure LA;Elliott AJ;Newschaffer CJ
邻苯二甲酸酯是一种被怀疑对胎儿神经发育有不利影响的化学物质，但对胎儿暴露量进行量化是一项挑战。虽然产前邻苯二甲酸盐暴露通常在母体尿液中量化，但新生儿的胎便可能更好地捕获累积产前暴露。目前，关于胎粪中邻苯二甲酸盐的测量数据很少。我们测量了183例妊娠中期和140例妊娠晚期（T2、T3）孕妇尿液中的邻苯二甲酸盐代谢物，以及收集自236例自闭症高危妊娠队列的190例胎粪样本。在超过90%的尿液和胎便样本中分别检测到11种和8种代谢物。两种生物样品均检测到亲水性和疏水性代谢物。大多数尿邻苯二甲酸盐代谢物分布在T2和T3之间相似。在两种生物样品中检测到的代谢物中，邻苯二甲酸二（2-乙基己基）酯的代谢物在不同代谢物类型中显示出相似的大小模式。具体来说，T2肌酐调整后的尿邻苯二甲酸单（2-乙基己基-羧戊基）（MECPP）、单（2-乙基-5-羟基己基）（MEHHP）和单（2-乙基-5-氧己基）酯（MEOHP）分布[中位数（25%,75%）]分别为18.8（11.9,31.4）、11.8（7.2,19.1）和8.9(6.2,14.2)ng/mg。在胎粪中，它们分别为16.6(10.9,23.7),2.5（1.5,3.8）和1.3(0.8,2.3)ng/g。粪中代谢物对代谢物的相关性低于尿，但模式相似。例如，邻苯二甲酸单（2-乙基己基）酯与MECPP之间的相关性（95% CI）为0.73(0.66,0.78)，尿中MEOHP和MEHHP之间的相关性（95% CI）为0.96(0.95,0.97)，而胎粪中MEOHP和MEHHP的相关性分别为0.10（- 0.04,0.24）和0.31（0.18,0.43）。尿和胎便中相同代谢物的相关性较低，代谢物和妊娠期的相关性不同。例如，尿中MEHHP与胎粪的相关性在T3时为0.20(0.008,0.37)，而在T2时为0.05（- 0.12,0.21）。我们的研究提供了一般人群水平的产前邻苯二甲酸盐暴露在神经发育障碍高危人群中的证据，并支持胎便测量产前邻苯二甲酸盐暴露的效用，但几乎没有证据表明与产前产妇尿液中测量的暴露相关。
Phthalates are chemicals suspected to adversely affect fetal neurodevelopment, but quantifying the fetal exposure is challenging. While prenatal phthalate exposure is commonly quantified in maternal urine, the newborn’s meconium may better capture cumulative prenatal exposure. Currently, data on phthalates measured in meconium is sparse. We measured phthalate metabolites in 183 maternal second and 140 third trimester (T2, T3) urine, and in 190 meconium samples collected in an autism enriched-risk pregnancy cohort of 236 mothers. Eleven and eight metabolites were detected in over 90% of urine and meconium samples, respectively. Hydrophilic and hydrophobic metabolites were detected in both biosamples. Most urine phthalate metabolite distributions were similar between T2 and T3. Among metabolites detected in both biosamples, those of di(2-ethylhexyl) phthalate displayed a similar pattern in magnitude across metabolite type. Specifically, T2 creatinine adjusted distribution [median (25%, 75%)] of urine measured mono(2-ethylhexyl-carboxypentyl) (MECPP), mono(2-ethyl-5-hydroxyhexyl) (MEHHP), and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) were 18.8(11.9, 31.4), 11.8(7.2, 19.1), and 8.9(6.2, 14.2) ng/mg. In meconium these were 16.6(10.9, 23.7), 2.5(1.5, 3.8), and 1.3(0.8, 2.3) ng/g, respectively. Metabolite-to-metabolite correlations were lower in meconium than urine, but patterns were similar. For example, correlation (95% CI) between mono(2-ethylhexyl) phthalate and MECPP was 0.73 (0.66, 0.78), and between MEOHP and MEHHP was 0.96 (0.95, 0.97) in urine as compared to 0.10 (−0.04, 0.24) and 0.31 (0.18, 0.43) respectively in meconium. Correlations between same metabolites measured in urine and meconium were low and differed by metabolite and trimester. Correlation between MEHHP in urine and meconium, for example, was 0.20 (0.008, 0.37) at T3, but 0.05 (−0.12, 0.21) at T2. Our study provides evidence of general population-level prenatal phthalate exposure in a population at high risk for neurodevelopmental disorders and supports the utility of meconium to measure prenatal phthalate exposure but provides little evidence of correlation with exposure measured in prenatal maternal urine.
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影响因子：
4.9
作者：
Newschaffer CJ;Croen LA;Fallin MD;Hertz-Picciotto I;Nguyen DV;Lee NL;Berry CA;Farzadegan H;Hess HN;Landa RJ;Levy SE;Massolo ML;Meyerer SC;Mohammed SM;Oliver MC;Ozonoff S;Pandey J;Schroeder A;Shedd-Wise KM
通讯作者：
Shedd-Wise KM
影响因子：
2.2
作者：
Mose, Tina;Knudsen, Lisbeth E.;Mortensen, Gerda K.
通讯作者：
Mortensen, Gerda K.
影响因子：
--
作者：
Koch, HM;Preuss, R;Angerer, J
通讯作者：
Angerer, J
影响因子：
8.3
作者：
LaRocca, Jessica;Binder, Alexandra M.;McElrath, Thomas F.;Michels, Karin B.
通讯作者：
Michels, Karin B.
影响因子：
10.4
作者：
Meeker JD;Hu H;Cantonwine DE;Lamadrid-Figueroa H;Calafat AM;Ettinger AS;Hernandez-Avila M;Loch-Caruso R;Téllez-Rojo MM
通讯作者：
Téllez-Rojo MM