Infant siblings and the investigation of autism risk factors.
Infant siblings and the investigation of autism risk factors.
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DOI：
10.1186/1866-1955-4-7
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发表时间：
2012-04-18
影响因子：
4.9
通讯作者：
Shedd-Wise KM
中科院分区：
文献类型：
--
作者：
Newschaffer CJ;Croen LA;Fallin MD;Hertz-Picciotto I;Nguyen DV;Lee NL;Berry CA;Farzadegan H;Hess HN;Landa RJ;Levy SE;Massolo ML;Meyerer SC;Mohammed SM;Oliver MC;Ozonoff S;Pandey J;Schroeder A;Shedd-Wise KM
在过去的十年中，婴儿兄弟姐妹的研究一直处于自闭症谱系障碍（ASD）研究的前沿，为ASD最早出现的迹象提供了重要的新知识，并扩大了我们对这种复杂疾病发展过程的理解。关注ASD患儿兄弟姐妹的研究在ASD病因学研究方面也有未被认识到的潜力。将登记的目标时间从婴儿期回到怀孕期，为在产前、围孕期和新生儿期最佳地研究风险因素和风险生物标志物创造了巨大的机会。通过这样做，传统的兄弟姐妹研究，已经包含了对有风险的婴儿在生命的第三年进行密切的发育跟踪，本质上被重新配置为一项高风险的妊娠队列研究。本文综述了在当前对ASD病因机制的思考背景下研究婴儿兄弟姐妹的高危妊娠队列方法。然后讨论了该方法的主要特点，并提供了一个主要的ASD高风险妊娠队列研究的设计和实施策略的描述：早期自闭症风险纵向调查（EARLI）。
Infant sibling studies have been at the vanguard of autism spectrum disorders (ASD) research over the past decade, providing important new knowledge about the earliest emerging signs of ASD and expanding our understanding of the developmental course of this complex disorder. Studies focused on siblings of children with ASD also have unrealized potential for contributing to ASD etiologic research. Moving targeted time of enrollment back from infancy toward conception creates tremendous opportunities for optimally studying risk factors and risk biomarkers during the pre-, peri- and neonatal periods. By doing so, a traditional sibling study, which already incorporates close developmental follow-up of at-risk infants through the third year of life, is essentially reconfigured as an enriched-risk pregnancy cohort study. This review considers the enriched-risk pregnancy cohort approach of studying infant siblings in the context of current thinking on ASD etiologic mechanisms. It then discusses the key features of this approach and provides a description of the design and implementation strategy of one major ASD enriched-risk pregnancy cohort study: the Early Autism Risk Longitudinal Investigation (EARLI).
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影响因子：
6.9
作者：
BAILEY, A;LECOUTEUR, A;RUTTER, M
通讯作者：
RUTTER, M
影响因子：
3.9
作者：
Bryson, Susan E.;Zwaigenbaum, Lonnie;Brian, Jessica
通讯作者：
Brian, Jessica
DOI：
10.1111/j.1469-7610.1994.tb02300.x
发表时间：
1994-07-01
影响因子：
7.6
作者：
BOLTON, P;MACDONALD, H;RUTTER, M
通讯作者：
RUTTER, M
DOI：
10.1352/1944-7558-116.5.331
发表时间：
2011-09-01
影响因子：
2.1
作者：
Bishop, Somer L.;Guthrie, Whitney;Lord, Catherine
通讯作者：
Lord, Catherine
影响因子：
11.8
作者：
Allen, Joseph G.;McClean, Michael D.;Webster, Thomas F.
通讯作者：
Webster, Thomas F.