Marijuana, Alcohol, and ED: Correlations with LUTS/BPH.
Marijuana, Alcohol, and ED: Correlations with LUTS/BPH.
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DOI：
10.1007/s11934-020-01031-9
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发表时间：
2021-02-08
影响因子：
2.6
通讯作者：
Malykhina A
中科院分区：
文献类型：
--
作者：
Lloyd GL;Wiesen B;Atwell M;Malykhina A
良性前列腺增生（BPH）和下尿路症状（LUTS）是一种具有巨大社会负担的疾病复合体，但对LUTS/BPH的发病机制知之甚少。我们回顾了抑郁症、大麻使用和勃起功能障碍（艾德）与LUTS/BPH之间关系的文献。LUTS/BPH与抑郁症以及ED有独立的关联。在每种情况下，因果关系和机制关系尚不清楚。大麻的影响，因为它越来越普遍的一般人群，对LUTS/BPH的疾病复合体没有得到很好的研究，但最近的结果支持短期利益和长期谨慎。抑郁症（一种中枢神经功能障碍）和艾德（可能通过内皮功能障碍介导）与LUTS/BPH独立相关。大麻素受体在泌尿器官中的存在，再加上最近的人口研究，支持大麻对排尿的调节作用，尽管仍然存在巨大的知识差距。
Benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) is a disease complex with enormous societal burden and yet the pathogenesis of LUTS/BPH is poorly understood. We set out to review the literature on the relationship between depression, marijuana usage, and erectile dysfunction (ED) to LUTS/BPH. LUTS/BPH has independent associations with depression as well as with ED. In each case, the causality and mechanistic relationship is unknown. The impact of marijuana, as it increasingly pervades the general population, on the disease complex of LUTS/BPH is not well studied but recent results support short-term benefit and long-term caution. Depression, a form of central nervous dysfunction, and ED, which is likely mediated via endothelial dysfunction, are independently associated with LUTS/BPH. The presence of cannabinoid receptors in urologic organs, coupled with recent population studies, supports a modulatory effect of marijuana on voiding although an enormous knowledge gap remains.
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