Organ-on-a-chip technology for the study of the female reproductive system.
Organ-on-a-chip technology for the study of the female reproductive system.
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DOI：
10.1016/j.addr.2021.03.010
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发表时间：
2021-06
影响因子：
16.1
通讯作者：
Huh DD
中科院分区：
文献类型：
--
作者：
Young RE;Huh DD
在过去的十年中，器官芯片和微生理系统已经成为生物制药应用的破坏性体外技术。通过使新的能力，工程生理活组织和器官单位在精确控制的环境中的微制造设备，这些系统提供了很大的希望，以推进前沿的基础和转化研究在生物医学科学。在这里，我们回顾了一个新兴的跨学科工作机构，旨在利用器官芯片技术的力量，用于生殖生物学和医学。这篇专题综述的重点是概述与药物递送和发现相关的微工程女性生殖器官模型的发展近况。我们介绍了这些先进的体外系统的工程设计，并检查其在妊娠，不孕不育和生殖疾病的研究中的应用。我们还提出了两个案例研究，使用器官芯片的设计原则来模拟胎盘药物转运和多个女性生殖器官之间的生殖调节串扰。最后，我们讨论了生殖器官芯片技术进步的挑战和机遇。
Over the past decade, organs-on-a-chip and microphysiological systems have emerged as a disruptive in vitro technology for biopharmaceutical applications. By enabling new capabilities to engineer physiological living tissues and organ units in the precisely controlled environment of microfabricated devices, these systems offer great promise to advance the frontiers of basic and translational research in biomedical sciences. Here, we review an emerging body of interdisciplinary work directed towards harnessing the power of organ-on-a-chip technology for reproductive biology and medicine. The focus of this topical review is to provide an overview of recent progress in the development of microengineered female reproductive organ models with relevance to drug delivery and discovery. We introduce the engineering design of these advanced in vitro systems and examine their applications in the study of pregnancy, infertility, and reproductive diseases. We also present two case studies that use organ-on-a-chip design principles to model placental drug transport and hormonally regulated crosstalk between multiple female reproductive organs. Finally, we discuss challenges and opportunities for the advancement of reproductive organ-on-a-chip technology.
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影响因子：
10
作者：
Blundell C;Yi YS;Ma L;Tess ER;Farrell MJ;Georgescu A;Aleksunes LM;Huh D
通讯作者：
Huh D
影响因子：
10
作者：
Abaci, Hasan E.;Guo, Zongyou;Coffman, Abigail;Gillette, Brian;Lee, Wen-han;Sia, Samuel K.;Christiano, Angela M.
通讯作者：
Christiano, Angela M.
影响因子：
4.6
作者：
Boretto, Matteo;Cox, Benoit;Vankelecom, Hugo
通讯作者：
Vankelecom, Hugo
DOI：
10.1098/rsif.2017.0131
发表时间：
2017-05
期刊：
Journal of the Royal Society, Interface
影响因子：
--
作者：
Abbas Y;Oefner CM;Polacheck WJ;Gardner L;Farrell L;Sharkey A;Kamm R;Moffett A;Oyen ML
通讯作者：
Oyen ML
影响因子：
14
作者：
Choi, Jung Kyu;Agarvval, Pranay;Huang, Haishui;Zhao, Shuting;He, Xiaoming
通讯作者：
He, Xiaoming